Application | Comment | Organism |
---|---|---|
medicine | the goal is to determine which metabolite of azathioprine has the most antiviral activity and to gain a better understanding of how this compound may act in vitro | Homo sapiens |
medicine | the goal is to determine which metabolite of azathioprine has the most antiviral activity and to gain a better understanding of how this compound may act in vitro | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Huh-7 cell | - |
Homo sapiens | - |
MDBK cell | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-thioinosine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside | - |
? | |
S-adenosyl-L-methionine + 6-thioinosine | - |
Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside | - |
? | |
S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? | |
S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Bos taurus | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Homo sapiens |
thiopurine methyltransferase | - |
Bos taurus |
TPMT | - |
Homo sapiens |
TPMT | - |
Bos taurus |