Application | Comment | Organism |
---|---|---|
medicine | while factors other than TPMT status are likely to be involved in azathioprine toxicity, the majority of evidence suggests that TPMT deficiency is a significant independent risk factor for myelotoxicity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
460G>A/719A>G | TPMT*3A polymorphism, low or no TPMT activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine | - |
? | |
S-adenosyl-L-methionine + 6-thioinosine 5'-monophosphate | - |
Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine ribonucleotide | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + azathioprine | azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT | Homo sapiens | S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thiopurine methyltransferase | - |
Homo sapiens |
TPMT | - |
Homo sapiens |