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Literature summary for 2.1.1.67 extracted from

  • Perri, D.; Cole, D.E.; Friedman, O.; Piliotis, E.; Mintz, S.; Adhikari, N.K.
    Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase (2007), Eur. Respir. J., 30, 1014-1017.
    View publication on PubMed

Application

Application Comment Organism
medicine while factors other than TPMT status are likely to be involved in azathioprine toxicity, the majority of evidence suggests that TPMT deficiency is a significant independent risk factor for myelotoxicity Homo sapiens

Protein Variants

Protein Variants Comment Organism
460G>A/719A>G TPMT*3A polymorphism, low or no TPMT activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
S-adenosyl-L-methionine + 6-thioinosine 5'-monophosphate
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine ribonucleotide
-
?
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?
S-adenosyl-L-methionine + azathioprine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens