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Literature summary for 2.1.1.67 extracted from

  • Bezier, M.; Reguiai, Z.; Vitry, F.; Broly, F.; Bernard, P.
    Thiopurine S-methyltransferase genotypic analysis in autoimmune bullous diseases (2008), Eur. J. Dermatol., 18, 512-517.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine thiopurine S-methyltransferase activity is inversely related to the risk of developing severe hematopoietic toxicity in patients treated with azathioprine Homo sapiens

Protein Variants

Protein Variants Comment Organism
238G>C TPMT variant, inactivating mutation in exon 5 Homo sapiens
460G>A TPMT variant, inactivating mutation in exon 7 Homo sapiens
719A>G TPMT variant, inactivating mutation in exon 10 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens