Application | Comment | Organism |
---|---|---|
medicine | individuals with decreased TPMT activity are at high risk of fatal adverse reactions if treated with conventional thiopurine doses | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
238G>C | TPMT variant | Homo sapiens |
460G>A | TPMT variant | Homo sapiens |
539A>T | TPMT variant | Homo sapiens |
719A>G | TPMT variant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a thiopurine | Homo sapiens | - |
S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 6-mercaptopurine | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + 6-thioguanine | - |
Homo sapiens | ? | - |
? | |
S-adenosyl-L-methionine + a thiopurine | - |
Homo sapiens | S-adenosyl-L-homocysteine + a thiopurine S-methylether | - |
? | |
S-adenosyl-L-methionine + azathioprine | - |
Homo sapiens | ? | - |
? |