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Literature summary for 2.1.1.67 extracted from

  • Hogarth, L.A.; Redfern, C.P.; Teodoridis, J.M.; Hall, A.G.; Anderson, H.; Case, M.C.; Coulthard, S.A.
    The effect of thiopurine drugs on DNA methylation in relation to TPMT expression (2008), Biochem. Pharmacol., 76, 1024-1035.
    View publication on PubMed

Application

Application Comment Organism
medicine thiopurine methyltransferase metabolises thiopurine drugs and influences their cytotoxic activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic kidney cell line embryonic kidney cell line with inducible thiopurine methyltransferase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens ?
-
?
S-adenosyl-L-methionine + 6-thioguanine
-
Homo sapiens ?
-
?
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens