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Literature summary for 2.1.1.67 extracted from

  • Roblin, X.; Biroulet, L.P.; Phelip, J.M.; Nancey, S.; Flourie, B.
    A 6-Thioguanine Nucleotide Threshold Level of 400 pmol/8 x 10(8) Erythrocytes Predicts Azathioprine Refractoriness in Patients With Inflammatory Bowel Disease and Normal TPMT Activity (2007), Am. J. Gastroenterol., 102, 1-8.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
normal thiopurine methyltransferase activity, 7.5-14 U/ml erythrocytes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
Homo sapiens
thiopurine S-methyltransferase
-
Homo sapiens
TPMT
-
Homo sapiens