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Literature summary for 2.1.1.67 extracted from

  • Winter, J.W.; Gaffney, D.; Shapiro, D.; Spooner, R.J.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
    Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease (2007), Aliment. Pharmacol. Ther., 25, 1069-1077.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine myelosuppression occurs in 2-7% of inflammatory bowel disease patients treated with azothioprine, and can be associated with reduced activity of thiopurine methyltransferase in some patients Homo sapiens

Protein Variants

Protein Variants Comment Organism
A154T/Y240C TPMT*3A polymorphismus Homo sapiens
A80P TPMT*2 polymorphismus Homo sapiens
Y240C TPMT*3C polymorphismus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine methyltransferase
-
 Homo sapiens