Literature summary for 2.1.1.67 extracted from

Winter, J.W.; Gaffney, D.; Shapiro, D.; Spooner, R.J.; Marinaki, A.M.; Sanderson, J.D.; Mills, P.R.
Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease (2007), Aliment. Pharmacol. Ther., 25, 1069-1077.

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Application

Application	Comment	Organism
medicine	myelosuppression occurs in 2-7% of inflammatory bowel disease patients treated with azothioprine, and can be associated with reduced activity of thiopurine methyltransferase in some patients	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A154T/Y240C	TPMT*3A polymorphismus	Homo sapiens
A80P	TPMT*2 polymorphismus	Homo sapiens
Y240C	TPMT*3C polymorphismus	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + a thiopurine	Homo sapiens	-	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 6-mercaptopurine	azathioprine is converted via a non-enzymatic reaction to mercaptopurine, which is subsequently metabolized through TPMT	Homo sapiens	S-adenosyl-L-homocysteine + 6-methylmercaptopurine	-	?
S-adenosyl-L-methionine + a thiopurine	-	Homo sapiens	S-adenosyl-L-homocysteine + a thiopurine S-methylether	-	?

Synonyms

Synonyms	Comment	Organism
thiopurine methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)