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Literature summary for 2.1.1.67 extracted from

  • Brouwer, C.; de Abreu, R.A.; Keizer-Garritsen, J.J.; Lambooy, L.H.; Ament, K.; ter Riet, P.G.; van Wering, E.R.; Trijbels, F.J.; Veerman, A.J.; Hoogerbrugge, P.M.; Bokkerink, J.P.
    Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects (2005), Eur. J. Cancer, 41, 613-623.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
analysis monitoring of TPMT activity may be of benefit to improve thiopurine therapy Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte TPMT activity is significantly lower in patients with acute lymphoblastic leukemia compared to control. Increase of TPMT activity during maintainance treatment with 6-mercaptopurine and already after induction therapy (treatment with antifolates, e.g. methotrexate and trimethoprim), before the patients receive 6-mercaptopurine Homo sapiens
-

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens