Literature summary for 2.1.1.67 extracted from

Brouwer, C.; de Abreu, R.A.; Keizer-Garritsen, J.J.; Lambooy, L.H.; Ament, K.; ter Riet, P.G.; van Wering, E.R.; Trijbels, F.J.; Veerman, A.J.; Hoogerbrugge, P.M.; Bokkerink, J.P.
Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects (2005), Eur. J. Cancer, 41, 613-623.

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Application

Application	Comment	Organism
analysis	monitoring of TPMT activity may be of benefit to improve thiopurine therapy	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	TPMT activity is significantly lower in patients with acute lymphoblastic leukemia compared to control. Increase of TPMT activity during maintainance treatment with 6-mercaptopurine and already after induction therapy (treatment with antifolates, e.g. methotrexate and trimethoprim), before the patients receive 6-mercaptopurine	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
thiopurine S-methyltransferase	-	Homo sapiens
TPMT	-	Homo sapiens

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Release 2023.1 (January 2023)