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Literature summary for 2.1.1.67 extracted from

  • Hamdan-Khalil, R.; Gala, J.L.; Allorge, D.; Lo-Guidice, J.M.; Horsmans, Y.; Houdret, N.; Broly, F.
    Identification and functional analysis of two rare allelic variants of the thiopurine S-methyltransferase gene, TPMT*16 and TPMT*19 (2005), Biochem. Pharmacol., 69, 525-529.
    View publication on PubMed
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Application

Application Comment Organism
medicine identification of a novel non-functional allele of the thiopurine S-methyltransferase gene enhances the efficiency of genotyping methods to predict patients at risk of an inadequate response to thiopurine therapy Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0152
-
 6-thioguanine
-
 Homo sapiens
0.0188
-
 6-thioguanine 1.2fold increase in KM-value compared to wild-type variant Homo sapiens
0.0448
-
 6-thioguanine 2.9fold increase in KM-value compared to wild-type variant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51580 wild-type variant TPMT*1
-
Homo sapiens P51580 variant Lys122Thr, i.e. variant TPMT*19, missense mutation in patients with Crohn's disease, patients heterozygous for the Lys122Thr mutation have normal TPMT activity
-
Homo sapiens P51580 variant Arg163His, i.e. variant TPMT*16, loss-of function allele of TPMT, patients heterozygous for the Arg163His mutation are intermediate methylators
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?

Synonyms

Synonyms Comment Organism
thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens