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Literature summary for 2.1.1.67 extracted from

  • Keizer-Garritsen, J.J.; Brouwer, C.; Lambooy, L.H.; Ter Riet, P.; Bokkerink, J.P.; Trijbels, F.J.; De Abreu, R.A.
    Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children (2003), Ann. Clin. Biochem., 40, 86-93.
    View publication on PubMed
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Application

Application Comment Organism
analysis monitoring of 6-thiopurine S-methyltransferase activity is especially important when patients are treated with 6-thiopurine drugs (drugs in treatment of acute lymphoblastic leukemia), since severe bone marrow toxicity may be induced if patients have deficient 6-thiopurine S-methyltransferase activity. The HPLC-based method enables the rapid screening of 6-6-thiopurine S-methyltransferase activities in patients treated with 6-thiopurines Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00665
-
 S-adenosyl-L-methionine Molt-F4 cell Homo sapiens
0.0119
-
 S-adenosyl-L-methionine erythrocyte Homo sapiens
0.0164
-
 S-adenosyl-L-methionine peripheral blood mononuclear cell Homo sapiens
0.54
-
 6-Mercaptopurine erythrocyte Homo sapiens
0.65
-
 6-Mercaptopurine Molt-F4 cell Homo sapiens
0.85
-
 6-Mercaptopurine peripheral blood mononuclear cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
MOLT-4F cell
-
 Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?

Synonyms

Synonyms Comment Organism
6-thiopurine S-methyltransferase
-
 Homo sapiens
TPMT
-
 Homo sapiens