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Literature summary for 2.1.1.67 extracted from

  • Stupans, I.; Kirlich, A.; McKinnon, R.A.
    Human thiopurine methyltransferase: no evidence of activation by its substrates (1997), Life Sci., 62, 343-350.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
baculovirus expressed Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2,8-dihydroxy-6-mercaptopurine
-
 Homo sapiens
2-Hydroxy-6-mercaptopurine
-
 Homo sapiens
6-thioguanine mixed inhibitor of 6-mercaptopurine methylation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.38
-
 6-Mercaptopurine kidney enzyme Homo sapiens
0.58
-
 6-Mercaptopurine liver enzyme Homo sapiens
0.99
-
 6-Mercaptopurine recombinant enzyme, baculovirus expressed Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.45
-
 6-thioguanine
-
 Homo sapiens
0.9
-
 6-thioguanine
-
 Homo sapiens