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Literature summary for 2.1.1.67 extracted from

  • Lysaa, R.A.; Giverhaug, T.; Wold, H.L.; Aarbakke, J.
    Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide (1996), Eur. J. Clin. Pharmacol., 49, 393-396.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-amino-salicylic acid
-
 Homo sapiens
bendroflumethiazide
-
 Homo sapiens
benzoic acid benzoic acid derivatives Homo sapiens
Furosemide
-
 Homo sapiens
sulphasalazine
-
 Homo sapiens
trichlormethiazide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens S-methylation, enzyme of major catabolic pathway of thiopurines S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine S-methylation, enzyme of major catabolic pathway of thiopurines Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?