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Literature summary for 2.1.1.67 extracted from

  • Krynetski, E.Y.; Krynetskaia, N.F.; Yanishevski, Y.; Evans, W.E.
    Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase (1995), Mol. Pharmacol., 47, 1141-1147.
    View publication on PubMed
Search for more literature for 2.1.1.67

Application

Application Comment Organism
medicine
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloning, heterologous expression in yeast Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0106
-
 6-Mercaptopurine recombinant enzyme, expressed in yeast Homo sapiens
0.0127
-
 6-thiodeoxyinosine recombinant enzyme, expressed in yeast Homo sapiens
0.0181
-
 6-thioguanine recombinant enzyme, expressed in yeast Homo sapiens
0.0257
-
 6-thioinosine 5'-monophosphate recombinant enzyme, expressed in yeast Homo sapiens
0.0261
-
 6-thioguanosine recombinant enzyme, expressed in yeast Homo sapiens
0.0271
-
 6-thioguanosine 5-monophosphate recombinant enzyme, expressed in yeast Homo sapiens
0.0551
-
 6-thioinosine recombinant enzyme, expressed in yeast Homo sapiens
0.1314
-
 6-thiodeoxyguanosine recombinant enzyme, expressed in yeast Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
leukocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thiodeoxyguanosine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-thiodeoxyguanosine S-methylether
-
 r
S-adenosyl-L-methionine + 6-thiodeoxyguanosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthiodeoxyguanosine monophosphate
-
 ?
S-adenosyl-L-methionine + 6-thiodeoxyinosine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-thiodeoxyinosine S-methylether
-
 r
S-adenosyl-L-methionine + 6-thiodeoxyinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methyl thiodeoxyinosine monophosphate
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine-riboside
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside
-
 ?
S-adenosyl-L-methionine + 6-thioguanosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methyl thioguanosine monophosphate
-
 ?
S-adenosyl-L-methionine + 6-thioinosine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine riboside
-
 ?
S-adenosyl-L-methionine + 6-thioinosine monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methyl thioinosine monophosphate
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?