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Literature summary for 2.1.1.67 extracted from

  • Deininger, M.; Szumlanski, C.L.; Otterness, D.M.; Van Loon, J.; Ferber, W.; Weinshilboum, R.M.
    Purine substrates for human thiopurine methyltransferase (1994), Biochem. Pharmacol., 48, 2135-2138.
    View publication on PubMed
Search for more literature for 2.1.1.67

Inhibitors

Inhibitors Comment Organism Structure
2,8-dihydroxy-6-mercaptopurine
-
 Homo sapiens
2-Hydroxy-6-mercaptopurine
-
 Homo sapiens
3,4-dimethoxy-5-hydroxybenzoic acid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0291
-
 6-selenopurine
-
 Homo sapiens
0.0518
-
 6-selenopurine-riboside
-
 Homo sapiens
0.0961
-
 8-hydroxy-6-mercaptopurine
-
 Homo sapiens
0.138
-
 6-hydroxy-8-mercaptopurine
-
 Homo sapiens
0.139
-
 6-selenoguanine-riboside
-
 Homo sapiens
0.159
-
 9-(n-propyl)-6-thioguanine
-
 Homo sapiens
0.231
-
 7-methyl-6-mercaptourine
-
 Homo sapiens
0.292
-
 9-(n-butyl)6-mercaptopurine
-
 Homo sapiens
0.372
-
 9-ethyl-6-mercaptopurine
-
 Homo sapiens
0.383
-
 6-Mercaptopurine
-
 Homo sapiens
0.557
-
 6-thioguanine
-
 Homo sapiens
0.761
-
 6-thioguanine-riboside
-
 Homo sapiens
0.89
-
 6-mercaptopurine-riboside-5'-triphosphate
-
 Homo sapiens
1.04
-
 6-thioguanine-riboside-5'-monophosphate
-
 Homo sapiens
1.17
-
 6-mercaptopurine-riboside
-
 Homo sapiens
1.27
-
 6-mercaptopurine-riboside-5'-monophosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
2 isozymes Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-hydroxy-8-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-hydroxy-8-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside
-
 ?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-monophosphate
-
 ?
S-adenosyl-L-methionine + 6-mercaptopurine-riboside-5'-triphosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine-riboside-5'-triphosphate
-
 ?
S-adenosyl-L-methionine + 6-selenoguanine-riboside
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylselenoguanine-riboside
-
 ?
S-adenosyl-L-methionine + 6-selenopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylselenopurine
-
 ?
S-adenosyl-L-methionine + 6-selenopurine-riboside
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylselenopurine-riboside
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine-riboside
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside
-
 ?
S-adenosyl-L-methionine + 6-thioguanine-riboside-5'-monophosphate
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine-riboside-5'-monophosphate
-
 ?
S-adenosyl-L-methionine + 7-methyl-6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + 8-hydroxy-6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 8-hydroxy-6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 9(n-propyl)6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 9(n-propyl)6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 9-(n-butyl)-6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 9-(n-butyl)-6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 9-ethyl-6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 9-ethyl-6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 3,4-dimethoxy-5-hydroxybenzoic acid
-
 Homo sapiens
0.027
-
 2-Hydroxy-6-mercaptopurine
-
 Homo sapiens