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Literature summary for 2.1.1.67 extracted from

  • Szumlanski, C.L.; Honchel, R.; Scott, M.C.; Weinshilboum, R.M.
    Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes (1992), Pharmacogenetics, 2, 148-159.
    View publication on PubMed
Search for more literature for 2.1.1.67

Inhibitors

Inhibitors Comment Organism Structure
S-adenosyl-L-homocysteine
-
 Homo sapiens
tropolone
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
 S-adenosyl-L-methionine cell lysate Homo sapiens
0.0027
-
 S-adenosyl-L-methionine
-
 Homo sapiens
0.29
-
 6-Mercaptopurine cell lysate Homo sapiens
0.3
-
 6-Mercaptopurine
-
 Homo sapiens
0.32
-
 6-Mercaptopurine
-
 Homo sapiens
0.58
-
 6-Mercaptopurine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Mus musculus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a thiopurine Mus musculus
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
erythrocyte
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Mus musculus
-
lymphocyte
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
80°C, activity in cell lysate is stable during storage Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Mus musculus S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Mus musculus S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?
S-adenosyl-L-methionine + a thiopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
3.5 8.6
-
 Homo sapiens