Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | - |
Mus musculus | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MGMT | - |
Mus musculus |
O6-methylguanine-DNA methyltransferase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | O6-methylguanine-DNA methyltransferase-deficient mice show a higher colon cancer frequency than the wild type | Mus musculus |
physiological function | O6-methylguanine reversal by the enzyme is required for protection against alkylation-induced colon carcinogenesis | Mus musculus |