Literature summary for 2.1.1.63 extracted from

Sabharwal, A.; Waters, R.; Danson, S.; Clamp, A.; Lorigan, P.; Thatcher, N.; Margison, G.P.; Middleton, M.R.
Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells (2011), Melanoma Res., 21, 502-508.

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Application

Application	Comment	Organism
medicine	determination of MGMT in peripheral blood mononuclear cells can identify patients at greatest risk of toxicity with O6-alkylating agent chemotherapy or who are suitable for dose intensification, MGMT protects against the toxic effects of O6-alkylating agents	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
peripheral blood mononuclear cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)