Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.63 extracted from

  • Buccoliero, A.M.; Castiglione, F.; Rossi Degl‘Innocenti, D.; Paglierani, M.; Maio, V.; Gheri, C.F.; Garbini, F.; Moncini, D.; Taddei, A.; Sardi, I.; Sanzo, M.; Giordano, F.; Mussa, F.; Genitori, L.; Taddei, G.L.
    O6-methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry (2008), J. Chemother., 20, 263-268.
    View publication on PubMed
Search for more literature for 2.1.1.63

Application

Application Comment Organism
medicine MGMT is a factor of chemoresistance to alkylating drugs in anaplastic ependymomas Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain tumor cell
-
 Homo sapiens
-
ependymoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ependymomas lack MGMT promoter hypermethylation and show high MGMT protein expression up