Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.63 extracted from

  • Hermes, M.; Geisler, H.; Osswald, H.; Riehle, R.; Kloor, D.
    Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation (2008), Biochem. Pharmacol., 75, 2100-2111.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
LN-18 cell
-
Homo sapiens
-
LN-229 cell
-
Homo sapiens
-
Tu-113 cell
-
Homo sapiens
-
Tu-132 cell
-
Homo sapiens
-
U-87MG cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
MGMT
-
Homo sapiens
O6-methylguanine-DNA methyltransferase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens neither short-term (24 h) nor long-term changes (7 weeks) in S-adenosyl-L-methionine/S-adenosylhomocysteine ratio alter global or MGMT promoter methylation, however, experimentally elevated S-adenosylhomocysteine levels significantly decrease MGMT mRNA levels by more than 50% down