Literature summary for 2.1.1.63 extracted from

Pearson, S.J.; Ferguson, J.; Santibanez-Koref, M.; Margison, G.P.
Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli (2005), Nucleic Acids Res., 33, 3837-3844.

Search for more literature for 2.1.1.63

Application

Application	Comment	Organism
analysis	overexpression of human MGMT provides protection against the toxic effects of N-methyl-N'-nitro-N-nitrosoguanidine	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli strain AB1157 and isogenic strain GWR111	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	MGMT W145 mutant does not inhibit methyl transfer by wild-type MGMT under the assay conditions used	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alkyltransferase-like protein	inhibits the transfer of methyl groups to MGMT, thus the action of MGMT on 6-O-methylguanine in DNA, inhibition is reversible by prolonged incubation in the presence of MGMT	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)