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Literature summary for 2.1.1.63 extracted from

  • Zang, H.; Fang, Q.; Pegg, A.E.; Guengerich, F.P.
    Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase (2005), J. Biol. Chem., 280, 30873-30881.
    View publication on PubMed
Search for more literature for 2.1.1.63

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
R128G reduces the AGT repair efficiency, no smaller effects with the O6-benzylguanine substrate than the 6-O-methylguanine Homo sapiens
R128L reduces the AGT repair efficiency, smaller effects with the O6-benzylguanine substrate than the 6-O-methylguanine Homo sapiens
Y114F reduces the AGT repair efficiency, smaller effects with the O6-benzylguanine substrate than the 6-O-methylguanine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-benzylguanine + [protein]-L-cysteine AGT binds and scans DNA rapidly, flips O6-alkylG residues, transfers the alkyl group in a chemical step that is not rate-limiting in the case of 6-O-benzylguanine and releases the dealkylated DNA Homo sapiens DNA lacking 6-O-benzylguanine + [protein]-S-methyl-L-cysteine
-
 ?
DNA containing 6-O-methylguanine + [protein]-L-cysteine AGT binds and scans DNA rapidly, flips O6-alkylG residues, transfers the alkyl group in a chemical step that is rate-limiting in the case of 6-O-methylguanine and releases the dealkylated DNA Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
AGT
-
 Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
 Homo sapiens