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Literature summary for 2.1.1.63 extracted from
- Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane (2006), Chem. Res. Toxicol., 19, 645-654.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,2,3,4-diepoxybutane | induces AGT-DNA cross-linking, takes place exclusively at the cysteine residues within the protein | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | AGT-DNA cross-linking is a likely mechanism of 1,2,3,4-diepoxybutane-mediated cytotoxicity in cells expressing this important repair protein | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C145A | abolishes 1,2,3,4-diepoxybutane-induced cross-linking at this site, while the formation of conjugates via neighboring Cys150 is retained | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGT | - |
Homo sapiens |
| O6-alkylguanine DNA alkyltransferase | - |
Homo sapiens |
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