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Literature summary for 2.1.1.63 extracted from

  • Liu, L.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E.
    O6-Alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate (2004), Chem. Res. Toxicol., 17, 742-752.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli TRG8 Homo sapiens

Protein Variants

Protein Variants Comment Organism
C145A inactive mutant protein Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BrCH2OAc reacts with the enzyme at its cysteine acceptor site, abolishing its DNA repair activity, the formation of AGT-Cys145S-CH2Br by BrCH2OAc Homo sapiens
CH2Br2 reacts with the enzyme at its cysteine acceptor site, abolishing its DNA repair activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 4-O-methylthymine + [protein-L-cysteine Homo sapiens DNA-repair enzyme DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 4-O-methylthymine + [protein-L-cysteine DNA-repair enzyme Homo sapiens DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
AGT
-
Homo sapiens
O6-alkylguanine-DNA alkyltransferase
-
Homo sapiens