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Literature summary for 2.1.1.63 extracted from
- Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase (1990), J. Biol. Chem., 265, 14754-14762.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 19000 | - |
gel filtration, glycerol density gradient sedimentation | Homo sapiens |
| 25000 | - |
1 * 25000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA containing 4-O-methylthymine + [protein-L-cysteine | - |
Homo sapiens | DNA lacking 4-O-methylthymine + [protein]-S-methyl-L-cysteine | - |
? |  |
| DNA containing 6-O-methylguanine + [protein]-L-cysteine | the methyltransferase protein itself accepts methyl groups from methylated DNA, one enzyme molecule accepts one methyl group | Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 25000, SDS-PAGE | Homo sapiens |
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Release 2023.1 (January 2023)
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