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Literature summary for 2.1.1.63 extracted from

  • Nutt, C.L.; Costello, J.F.; Bambrick, L.L.; Yarosh, D.B.; Swinnen, L.J.; Chambers, A.F.; Cairncross, J.G.
    O6-Methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage (1995), Can. J. Neurol. Sci., 22, 111-115.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte low activity Homo sapiens
-
oligodendrocyte
-
Rattus norvegicus
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oligodendroglioma cell low 6-O-methylguanine-DNA methyltransferase activity may contribute to the chemosensitivity of some human oligodendrogliomas Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
Rattus norvegicus DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
?