Literature summary for 2.1.1.63 extracted from

Inui, H.; Watatani, M.; Yasutomi, M.; Nishisho, I.
Comparison of O6-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea (1994), Carcinogenesis, 15, 459-463.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	Rattus norvegicus	the DNA repair enzyme can specifically remove methyl groups from 6-O-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-A transition	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mammary tumor cell	no statistically significant difference in the amount of enzyme between tumors with and without activated H1-ras oncogene	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Rattus norvegicus	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?
DNA containing 6-O-methylguanine + [protein]-L-cysteine	the DNA repair enzyme can specifically remove methyl groups from 6-O-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-A transition	Rattus norvegicus	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

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Release 2023.1 (January 2023)