Protein Variants | Comment | Organism |
---|---|---|
C145A | inactive mutant enzyme forms a specific and stable complex with a 6-O-methylguanine-containing oligonucleotide substrate | Homo sapiens |
C145S | inactive mutant enzyme forms a specific and stable complex with a 6-O-methylguanine-containing oligonucleotide substrate | Homo sapiens |
additional information | deletion of more than 8 or 31 residues from the amino or carboxyl terminus, respectively, leads to the loss of both activity and substrate binding. Removal of Arg9 or Leu176 and distal residues inactivates the protein | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the alkyl group is transferred without a cofactor to Cys145 residue of the enzyme and thereby inactivates the protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 6-O-methylguanine + [protein]-L-cysteine | the alkyl group is transferred without a cofactor to Cys145 residue of the enzyme and thereby inactivates the protein | Homo sapiens | DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine | - |
? |