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Literature summary for 2.1.1.61 extracted from
- Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase (2004), Biochim. Biophys. Acta, 1676, 119-126.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene trmU, DNA and amino acid sequence determination and analysis, expression in NIH3T3 cells mitochondria as N-terminal GFP-fusion protein | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 47240 | - |
x * 47240, amino acid sequence calculation | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA | Mus musculus | enzyme plays a role in tRNA modification and protein synthesis, pivotal in the fidelity of the translational process | S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9DAT5 | gene trmU | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| additional information | the trmU gene is expressed in various tissues, but abundantly in tissues with high metabolic rates | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA | enzyme plays a role in tRNA modification and protein synthesis, pivotal in the fidelity of the translational process | Mus musculus | S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA | - |
? | |
| S-adenosyl-L-methionine + 5-aminomethyl-2-thiouridine in tRNA | nucleotide modification at the wobble position 34 of anticodons | Mus musculus | S-adenosyl-L-homocysteine + 5-methylaminomethyl-2-thiouridylate in tRNA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 47240, amino acid sequence calculation | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-methylaminomethyl-2-thiouridylate-methyltransferase | - |
Mus musculus |
| TRMU | - |
Mus musculus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Mus musculus | amino acid sequence calculation | - |
8.7 |
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