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Literature summary for 2.1.1.60 extracted from

  • Wright, L.S.; Bertics, P.J.; Siegel, F.L.
    Calmodulin N-methyltransferase. Kinetics, mechanism, and inhibitors (1996), J. Biol. Chem., 271, 12737-12743.
    View publication on PubMed
Search for more literature for 2.1.1.60

Inhibitors

Inhibitors Comment Organism Structure
Calmidazolium
-
 Rattus norvegicus
S-adenosylhomocysteine
-
 Rattus norvegicus
trimethyllysine calmodulin
-
 Rattus norvegicus
VU-3 Calmodulin
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00023
-
 mushroom demethylcalmodulin
-
 Rattus norvegicus
0.002
-
 S-adenosyl-L-methionine
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine Bi Bi sequential mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine mushroom demthylcalmodulin Rattus norvegicus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine trimethyllysine calmodulin, major product, + dimethyllysine + monomethyllysine ?
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Escherichia coli S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + mushroom demethylcalmodulin
-
 Rattus norvegicus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00031
-
 trimethyllysine calmodulin
-
 Rattus norvegicus
0.0004
-
 VU-3 Calmodulin
-
 Rattus norvegicus