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Literature summary for 2.1.1.60 extracted from

  • Sitaramayya, A.; Wright, L.S.; Siegel, F.L.
    Enzymatic methylation of calmodulin in rat brain cytosol (1980), J. Biol. Chem., 255, 8894-8900.
    View publication on PubMed
Search for more literature for 2.1.1.60

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol stimulates Rattus norvegicus
Mn2+ stimulation by divalent cations, Mn2+ giving highest activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Rattus norvegicus
p-chloromercuriphenylsulfonic acid
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ stimulation by divalent cations, Mn2+ giving highest activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine highly specific Rattus norvegicus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine trimethyllysine calmodulin, major product, + dimethyllysine + monomethyllysine ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 pH 8.0, 7.8 or 6.0 depending on assay method Rattus norvegicus