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Literature summary for 2.1.1.60 extracted from

  • Magen, S.; Magnani, R.; Haziza, S.; Hershkovitz, E.; Houtz, R.; Cambi, F.; Parvari, R.
    Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence (2012), PLoS ONE, 7, e52425.
    View publication on PubMed
Search for more literature for 2.1.1.60

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Mus musculus 5737
-
Golgi apparatus short isoform Homo sapiens 5794
-
Golgi apparatus
-
 Mus musculus 5794
-
nucleus
-
 Homo sapiens 5634
-
nucleus
-
 Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, SDS-PAGE Mus musculus
36000
-
 x * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine Homo sapiens
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + calmodulin L-lysine Mus musculus
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q7Z624
-
-
Mus musculus Q3U2J5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Homo sapiens S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + calmodulin L-lysine
-
 Mus musculus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Subunits

Subunits Comment Organism
? x * 36000, SDS-PAGE Homo sapiens
? x * 36000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
calmodulin methyltransferase
-
 Homo sapiens
calmodulin methyltransferase
-
 Mus musculus
CaM KMT previously C2orf34 Homo sapiens
CaM KMT
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the absence of enzyme causes accumulation of hypomethylated calmodulin in 2p21 deletion syndrome patients Homo sapiens
metabolism the enzyme is the major methyltransferase of calmodulin in human cells and a Hsp90 client protein Homo sapiens