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Literature summary for 2.1.1.6 extracted from

  • Qi, Q.; Cao, L.; Li, F.; Wang, H.; Liu, H.; Hao, H.; Hao, K.
    Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats (2015), Xenobiotica, 45, 820-827.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
salvianolic acid B weak inhibitor. In vivo, a single intravenous dose of salvianolic acid B decreases the plasma concentration of 3-O-methyldopa, with no obvious effect on the pharmacokinetics of L-dopa Rattus norvegicus
tolcapone strongly inhibits the formation of 3-methylsalvianolic acid B in vitro and in vivo, without any change in its plasma concentration. Tolcapone significantly increases the cumulative bile excretion of salvianolic acid from 3% to 40% in the rat Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0113
-
salvianolic acid B lung tissue preparation, 37°C, pH not specified in the publication Rattus norvegicus
0.0162
-
salvianolic acid B intestine tissue preparation, 37°C, pH not specified in the publication Rattus norvegicus
0.07
-
salvianolic acid B kidney tissue preparation, 37°C, pH not specified in the publication Rattus norvegicus
0.0797
-
salvianolic acid B liver tissue preparation, 37°C, pH not specified in the publication Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-dopa + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + 3-O-methyl-L-dopa
-
?
salvianolic acid B + S-adenosyl-L-methionine
-
Rattus norvegicus S-adenosyl-L-homocysteine + ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0021
-
salvianolic acid B 37°C, pH not specified in the publication Rattus norvegicus