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Literature summary for 2.1.1.6 extracted from

  • Zeng, B.Y.; Balfour, R.H.; Jackson, M.J.; Rose, S.; Jenner, P.
    Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets (2010), J. Neural Transm., 117, 45-51.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information COMT activity appears unaffected by loss of the dopaminergic nigrostriatal pathway and levodopa treatment Callithrix jacchus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane MB-COMT Callithrix jacchus 16020
-
soluble S-COMT Callithrix jacchus
-
-

Organism

Organism UniProt Comment Textmining
Callithrix jacchus
-
common marmoset
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex
-
Callithrix jacchus
-
liver
-
Callithrix jacchus
-
striatum
-
Callithrix jacchus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa + S-adenosyl-L-methionine
-
Callithrix jacchus S-adenosyl-L-homocysteine + 3-O-methyldopa
-
?

Synonyms

Synonyms Comment Organism
COMT
-
Callithrix jacchus
MB-COMT membrane-bound COMT Callithrix jacchus
S-COMT soluble COMT Callithrix jacchus