Literature summary for 2.1.1.6 extracted from

Ho, P.W.; Garner, C.E.; Ho, J.W.; Leung, K.C.; Chu, A.C.; Kwok, K.H.; Kung, M.H.; Burka, L.T.; Ramsden, D.B.; Ho, S.L.
Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk (2008), Curr. Drug Metab., 9, 304-309.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-hydroxyestradiol + S-adenosyl-L-methionine	-	Homo sapiens	S-adenosyl-L-homocysteine + ?	-	?

Synonyms

Synonyms	Comment	Organism
COMT	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	COMT protein expression levels are statistically significantly reduced by both, catechol and phenolic metabolites of polychlorinated biphenyls: 2,5-dichlorobiphenyl, 2',5'-dichlorobiphenyl-2-ol, 2',5'-dichlorobiphenyl-2,3-diol, 2',5'-dichlorobiphenyl-3,4-diol, 2',5'-dichlorobiphenyl-4-ol, 2',4'-dichlorobiphenyl-4-ol, 2',4',6'-trichlorobiphenyl-4-ol, 2',4',6'-trichlorobiphenyl-3,4-diol, and 2',4',5'-trichlorobiphenyl-3,4-diol. The changes in COMT expression are abolished in the presence of the anti-estrogen ICI182780	down

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Release 2023.1 (January 2023)