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Literature summary for 2.1.1.6 extracted from

  • Overbye, A.; Seglen, P.O.
    Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues (2009), Biochem. J., 417, 535-545.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
membrane
-
Rattus norvegicus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
isoform S-COMT, SDS-PAGE Rattus norvegicus
28000
-
isoform L-COMT, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain L-COMT is the predominant enzyme form Rattus norvegicus
-
heart L-COMT is the predominant enzyme form Rattus norvegicus
-
hepatocyte
-
Rattus norvegicus
-
kidney S-COMT isoforms are highly and preferentially expressed in kidney Rattus norvegicus
-
liver S-COMT isoforms are highly expressed in liver, liver displays a very weak expression of L-COMT isoforms Rattus norvegicus
-
lung L-COMT is the predominant enzyme form Rattus norvegicus
-
additional information both of the L-COMT isoforms are found in all of the tissues examined except the heart, which expresses only the most acidic form, and the kidney, which expresses only the most basic form Rattus norvegicus
-
spleen L-COMT is the predominant enzyme form Rattus norvegicus
-
submandibular salivary gland L-COMT is the predominant enzyme form Rattus norvegicus
-
testis L-COMT is the predominant enzyme form Rattus norvegicus
-
thymus L-COMT is the predominant enzyme form Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
L-COMT large variant of catechol O-methyltransferase Rattus norvegicus
S-COMT small variant of catechol O-methyltransferase Rattus norvegicus