Literature summary for 2.1.1.6 extracted from

Helkamaa, T.; Reenilae, I.; Tuominen, R.K.; Soinila, S.; Vaeaenaenen, A.; Tilgmann, C.; Rauhala, P.
Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion (2007), Neurochem. Int., 51, 412-423.

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Application

Application	Comment	Organism
medicine	catechol-O-methyltransferase activity and protein expression are increased in the substantia nigra after inflammation induced by lipopolysaccharides. These changes in glial and perivascular catechol-O-methyltransferase activity may have clinical relevance for Parkinsons disease drug treatment due to increased metabolism of levodopa in the brain	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	paranigral lipopolysaccharide infusion to rats results in intense microglial activation around the lesion area followed by a delayed injury in nigrostriatal pathway in 2 weeks. Simultaneously, catechol-O-methyltransferase activity in the substantia nigra is gradually increased up to 213%. Soluble COMT and membrane bound COMT proteins are increased by 255% and 86%, respectively. Increased catechol-O-methyltransferase immunoreactivity is located primarily into the activated microglial cells in the lesion area	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
COMT	-	Rattus norvegicus

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Release 2023.1 (January 2023)