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Literature summary for 2.1.1.6 extracted from

  • Mantione, K.J.; Cadet, P.; Zhu, W.; Kream, R.M.; Sheehan, M.; Fricchione, G.L.; Goumon, Y.; Esch, T.; Stefano, G.B.
    Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition (2008), Addict. Biol., 13, 118-123.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
leukocyte leukocyte exposure to morphine down-regulates catechol-O-methyl transferase and CYP2D6 by approximately 50% compared with control values. Exposure of white blood cells to 0.001 mM S-nitroso-N-acetyl-DL-penicillamine, a nitric oxide donor, reduces the expression of CYP2D6 and COMT. Prior naloxone (0.001 mM) or N-nitro-L-arginine methyl ester (0.1 mM) addition abrogates down-regulating activity of morphine, demonstrating morphine is initiating its actions via stimulating constitutive NO synthase derived NO release via the mu3 opiate receptor splice variant Homo sapiens
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Synonyms

Synonyms Comment Organism
catechol-O-methyl transferase
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Homo sapiens
COMT
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Homo sapiens