Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.6 extracted from

  • Ball, P.; Knuppen, R.; Haupt, M.; Breuer, H.
    Kinetic properties of a soluble catechol O-methyltransferase of human liver (1972), Eur. J. Biochem., 26, 560-569.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cysteine required Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-Hydroxyestradiol-17beta 3-methyl ether product inhibition Homo sapiens
2-methoxyestradiol-17beta product inhibition Homo sapiens
Mg2+ required for activity Homo sapiens
additional information substrate inhibition is dependent on the concentration of S-adenosylmethionine and MgCl2 Homo sapiens
S-adenosyl-L-homocysteine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
2-hydroxyestradiol-17beta
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mn2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine
-
Homo sapiens 2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
42
-
2-hydroxyestradiol-17beta Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 8.4 leads to maximal formation of 2-methoxyestradiol-17beta Homo sapiens
9.2
-
leads to maximal formation of 2- and 3-monomethyl ether Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.039
-
S-adenosyl-L-homocysteine
-
Homo sapiens