Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cysteine | required | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Hydroxyestradiol-17beta 3-methyl ether | product inhibition | Homo sapiens | |
2-methoxyestradiol-17beta | product inhibition | Homo sapiens | |
Mg2+ | required for activity | Homo sapiens | |
additional information | substrate inhibition is dependent on the concentration of S-adenosylmethionine and MgCl2 | Homo sapiens | |
S-adenosyl-L-homocysteine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
2-hydroxyestradiol-17beta | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mn2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxyestradiol-17beta + S-adenosyl-L-methionine | - |
Homo sapiens | 2-methoxyestradiol-17beta + 2-hydroxyestradiol-17beta methyl ether + S-adenosyl-L-homocysteine | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
42 | - |
2-hydroxyestradiol-17beta | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | 8.4 | leads to maximal formation of 2-methoxyestradiol-17beta | Homo sapiens |
9.2 | - |
leads to maximal formation of 2- and 3-monomethyl ether | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
S-adenosyl-L-homocysteine | - |
Homo sapiens |