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Literature summary for 2.1.1.57 extracted from

  • Szretter, K.J.; Daniels, B.P.; Cho, H.; Gainey, M.D.; Yokoyama, W.M.; Gale, M.; Virgin, H.W.; Klein, R.S.; Sen, G.C.; Diamond, M.S.
    2-O methylation of the viral mRNA cap by West Nile virus evades Ifit1-dependent and -independent mechanisms of host restriction in vivo (2012), PLoS Pathog., 8, e1002698.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.57

Protein Variants

Protein Variants Comment Organism
E218A the mutation abolishes 2'-O-methyltransferase activity and enhances replication but not virulence in Ifit1-deficient mice after peripheral infection West Nile virus

Organism

Organism UniProt Comment Textmining
West Nile virus
-
-
-

Synonyms

Synonyms Comment Organism
2'-O methyltransferase
-
 West Nile virus
NS5
-
 West Nile virus

General Information

General Information Comment Organism
malfunction viruses lacking 2'-O methyltransferase activity exhibit attenuation in primary macrophages West Nile virus