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Literature summary for 2.1.1.57 extracted from

  • Arhin, G.K.; Li, H.; Ullu, E.; Tschudi, C.
    A protein related to the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei (2006), RNA, 12, 53-62.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information related to the vaccinia virus VP39 cap 2'-O-methyltransferase, may has a minor role in the biogenesis of the SL RNA cap 4 structure Trypanosoma brucei
additional information relatively low overall sequence conservation between vaccinia virus VP39 and TbMT57, has a major role in the biogenesis of the SL RNA cap 4 structure Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
K266A proteins similar to that of the wild-type TbMT57-HA protein, defective in the biogenesis of the SL cap 4 structure Trypanosoma brucei
additional information trans-splicing utilization of the SL RNA is not detectably affected in mt57-/- cells, SS1 proteins similar to that of the wild-type TbMT57-HA protein, defective in the biogenesis of the SL cap 4 structure Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Trypanosoma brucei 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
-
Trypanosoma brucei
57000
-
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q385S9
-
-
Trypanosoma brucei Q38DJ3
-
-

Synonyms

Synonyms Comment Organism
cap-specific 2'-O-methyltransferase
-
Trypanosoma brucei
MT57
-
Trypanosoma brucei
TbMT48
-
Trypanosoma brucei
TbMT57
-
Trypanosoma brucei