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Literature summary for 2.1.1.5 extracted from

  • Collinsova, M.; Castro, C.; Garrow, T.A.; Yiotakis, A.; Dive, V.; Jiracek, J.
    Combining combinatorial chemistry and affinity chromatography: highly selective inhibitors of human betaine: homocysteine S-methyltransferase (2003), Chem. Biol., 10, 113-122.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ac-Val-Ala-Leu-His-NH2 0.1 mM, 25.9% inhibition Homo sapiens
Ac-Val-DL-Ala-psi[(PO2-)-CH2]-DL-Leu-His-NH2 0.1 mM, 57.4% inhibition Homo sapiens
Ac-Val-DL-Phe-psi[(PO2-)-CH2]-DL-Ala-His-NH2 0.1 mM, 8.7% inhibition Homo sapiens
Ac-Val-DL-Phe-psi[(PO2-)-CH2]-DL-Leu-His-NH2 0.1 mM, 53.7% inhibition Homo sapiens
additional information no inhibition by Ac-Val-DL-Ala-psi[(PO2-)-CH2]-DL-Leu-Cys-NH2, Ac-DL-Ala-psi[(PO2-)-CH2]-DL-Leu-NH2, Ac-Val-DL-Ala-psi[(PO2-)-CH2]-DL-Leu-His Homo sapiens
Val-DL-Ala-psi[(PO2-)-CH2]-DL-Leu-His-NH2 0.1 mM, 70.6% inhibition Homo sapiens
Val-DL-Phe-psi[(PO2-)-CH2]-DL-Leu-His-NH2 0.1 mM, 80.3% inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-homocysteine + betaine
-
Homo sapiens L-methionine + dimethylglycine
-
?

Synonyms

Synonyms Comment Organism
betaine:homocysteine S-methyltransferase
-
Homo sapiens