KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.25 | - |
beta-phenylethylamine | 5-methyltetrahydrofolate as methyl donor | Rattus norvegicus | |
8.3 | - |
tryptamine | 5-methyltetrahydrofolate as methyl donor | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley strain male rats | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000038 | - |
beta-phenylethylamine + S-adenosyl-L-methionine | Rattus norvegicus |
0.00000118 | - |
tryptamine + S-adenosyl-L-methionine | Rattus norvegicus |
0.000065 | - |
beta-phenylethylamine + 5-methyltetrahydrofolate | Rattus norvegicus |
0.000198 | - |
tryptamine + 5-methyltetrahydrofolate | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + alpha-N-methyltryptamine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + alpha,alpha-N,N-dimethyltryptamine | N,N-dimethyltryptamine as product | ? | |
S-adenosyl-L-methionine + beta-phenylethylamine | 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor | Rattus norvegicus | ? | - |
? | |
S-adenosyl-L-methionine + tryptamine | two N-methyltransferases, non-specific or specific for tryptamine, 5-methyltetrahydrofolate can replace S-adenosyl-L-methionine as methyl donor | Rattus norvegicus | S-adenosyl-L-homocysteine + alpha-N-methyltryptamine | - |
? | |
S-adenosyl-L-methionine + tryptamine | i.e. 3-[2-aminoethyl] indole, best substrate, two N-methyltransferases: A and B, non-specific | Rattus norvegicus | S-adenosyl-L-homocysteine + alpha-N-methyltryptamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aromatic alkylamine-N-methyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7 | 5-methyltetrahydrofolate as donor | Rattus norvegicus |
7.9 | - |
S-adenosyl-L-methionine as donor | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Rattus norvegicus |