Literature summary for 2.1.1.45 extracted from

Li, X.Y.; Liang, J.W.; Mohamed O, K.; Zhang, T.J.; Lu, G.Q.; Meng, F.H.
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs (2018), Eur. J. Med. Chem., 154, 267-279 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
N'-(3-chlorobenzoyl)-2-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide	IC50 value 0.00126 mM for A-549 cells, 0.00208 mM for OVCAR-3 cells, 0.00182 mM for SCG-7901 cells, 0.00442 mM for MDA-MB-231 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P04818	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
OVCAR-3 cell	-	Homo sapiens	-
SGC-7901 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)