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Literature summary for 2.1.1.45 extracted from

  • Amin, L.H.T.; Shawer, T.Z.; El-Naggar, A.M.; El-Sehrawi, H.M.A.
    Design, synthesis, anticancer evaluation and docking studies of new pyrimidine derivatives as potent thymidylate synthase inhibitors (2019), Bioorg. Chem., 91, 103159 .
    View publication on PubMed
Search for more literature for 2.1.1.45

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of inhibitors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-phenylthiosemicarbazide
-
 Homo sapiens
2-(2-(4-hydroxybenzylidene)hydrazinyl)-6-oxo-4-(p-tolyl)-1,6-dihydropyrimidine-5-carbonitrile
-
 Homo sapiens
2-chloro-N'-[5-methyl-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetohydrazide
-
 Homo sapiens
2-hydrazinyl-1,6-dihydro-6-oxo-4-p-tolyl pyrimidine-5-carbonitrile
-
 Homo sapiens
4-chloro-N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide
-
 Homo sapiens
N',N'-diacetyl-N-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)acetohydrazide compound induces the level of active caspase 3, and elevates the Bax/Bcl2 ratio 44fold in comparison to the control Homo sapiens
N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-nitrobenzohydrazide
-
 Homo sapiens
N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P04818
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000037
-
 pH 7.4, 30°C Homo sapiens N',N'-diacetyl-N-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)acetohydrazide
0.0000042
-
 pH 7.4, 30°C Homo sapiens N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-nitrobenzohydrazide
0.0000044
-
 pH 7.4, 30°C Homo sapiens 2-hydrazinyl-1,6-dihydro-6-oxo-4-p-tolyl pyrimidine-5-carbonitrile
0.0000046
-
 pH 7.4, 30°C Homo sapiens 1-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)-4-phenylthiosemicarbazide
0.0000047
-
 pH 7.4, 30°C Homo sapiens 4-chloro-N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide
0.0000081
-
 pH 7.4, 30°C Homo sapiens 2-chloro-N'-[5-methyl-4-(4-methylphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetohydrazide
0.000013
-
 pH 7.4, 30°C Homo sapiens 2-(2-(4-hydroxybenzylidene)hydrazinyl)-6-oxo-4-(p-tolyl)-1,6-dihydropyrimidine-5-carbonitrile
0.0000157
-
 pH 7.4, 30°C Homo sapiens N'-(5-cyano-1,6-dihydro-6-oxo-4-p-tolylpyrimidin-2-yl)benzohydrazide