Literature summary for 2.1.1.45 extracted from

Jung, W.S.; Shin, S.; Park, I.K.
Novobiocin inhibits the self-splicing of the primary transcripts of T4 phage thymidylate synthase gene (2008), Mol. Cell. Biochem., 314, 143-149.

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Inhibitors

Inhibitors	Comment	Organism	Structure
novobiocin	coumarin antibiotic produced by Streptomyces nivens, at 10 mM concentration the self-splicing of primary transcripts is inhibited by about 5%, at 40 mM concentration the splicing rate is inhibited by about 50%. The splicing inhibition is strongly dependent on Mg2+	Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	Tequatrovirus T4	-	7,8-dihydrofolate + dTMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + dUMP	-	Tequatrovirus T4	7,8-dihydrofolate + dTMP	-	?

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Release 2023.1 (January 2023)