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Literature summary for 2.1.1.45 extracted from

  • Balinska, M.; Rhee, M.; Whiteley, J.M.; Priest, D.G.; Galivan, J.
    Inhibition of mammalian thymidylate synthase by 10-formyltetrahydropteroylpolyglutamate (1991), Arch. Biochem. Biophys., 284, 219-222.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
10-formyl-7,8 dihydrofolate-tetra-gamma-L-glutamate
-
Homo sapiens
10-formyldihydropteroylglutamate
-
Rattus norvegicus
10-formyldihydropteroylheptaglutamate
-
Rattus norvegicus
10-formyldihydropteroylpentaglutamate
-
Homo sapiens
10-formyltetrahydrofolate
-
Rattus norvegicus
10-Formyltetrahydrofolylheptaglutamate
-
Rattus norvegicus
10-Formyltetrahydrofolylmonoglutamate
-
Rattus norvegicus
10-formyltetrahydropteroylheptaglutamate
-
Rattus norvegicus
10-formyltetrahydropteroylmonoglutamate
-
Mus musculus
10-formyltetrahydropteroylpolyglutamate
-
Rattus norvegicus
5,10-methenyltetrahydrofolylhexa-gamma-L-glutamate
-
Homo sapiens
dihydropteroylpentaglutamate
-
Homo sapiens
N10-formyltetrahydrofolate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00068
-
5,10-formyltetrahydropteroylheptaglutamate
-
Rattus norvegicus
0.00074
-
5,10-methenyltetrahydropteroylpentaglutamate
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Mus musculus
-
dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP Homo sapiens
-
dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP Rattus norvegicus
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
HeLa cells
-
Homo sapiens
-
MCF-7 breast cancer cells
-
Mus musculus
-
Ehrlich ascites carcinoma cells
-
Rattus norvegicus
-
rat
-
Rattus norvegicus
-
H35 hepatoma cells
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-formyltetrahydropteroylheptaglutamate + dUMP
-
Rattus norvegicus ?
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Homo sapiens dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Homo sapiens dihydrofolate + dTMP
-
r
5,10-methylenetetrahydrofolate + dUMP
-
Rattus norvegicus dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Rattus norvegicus dihydrofolate + dTMP
-
r
5,10-methylenetetrahydrofolylheptaglutamate + 2'-deoxyuridylate
-
Rattus norvegicus 7,8-dihydrofolylheptaglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydrofolylpentaglutamate + 2'-deoxyuridylate
-
Rattus norvegicus 7,8-dihydrofolylpentaglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydropteroylheptaglutamate + 2'-deoxyuridylate
-
Homo sapiens 7,8-dihydropteroylheptaglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydropteroylheptaglutamate + 2'-deoxyuridylate
-
Rattus norvegicus 7,8-dihydropteroylheptaglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydropteroylpentaglutamate + 2'-deoxyuridylate
-
Homo sapiens 7,8-dihydropteroylpentaglutamate + thymidine phosphate
-
r
5,10-methylenetetrahydropteroylpentaglutamate + 2'-deoxyuridylate
-
Rattus norvegicus 7,8-dihydropteroylpentaglutamate + thymidine phosphate
-
r
[6R,S]-5,10-methylenetetrahydropteroylglutamate + 2'-deoxyuridylate
-
Mus musculus ?
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
10-Formyltetrahydrofolylheptaglutamate
-
Rattus norvegicus
0.0007
-
10-formyldihydropteroylheptaglutamate
-
Rattus norvegicus
0.0016
-
10-formyldihydropteroylpentaglutamate
-
Homo sapiens
0.0024
-
10-Formyltetrahydrofolylmonoglutamate
-
Rattus norvegicus
0.0075
-
10-formyldihydropteroylglutamate
-
Rattus norvegicus
0.02
-
10-formyltetrahydropteroylmonoglutamate
-
Mus musculus