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Literature summary for 2.1.1.45 extracted from

  • Chen, S.C.; Daron, H.H.; Aull, J.L.
    Inhibition of thymidylate synthase by pyridoxal phosphate (1989), Int. J. Biochem., 21, 1217-1221.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
pyridoxal 5'-phosphate
-
Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Lacticaseibacillus casei
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Lacticaseibacillus casei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Lacticaseibacillus casei dihydrofolate + dTMP
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.6 0.9 pyridoxal 5'-phosphate
-
Lacticaseibacillus casei