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Literature summary for 2.1.1.45 extracted from

  • Sani, B.P.; Vaid, A.; Cory, J.G.; Brockman, R.W.; Elliott, R.D.; Montgomery, J.A.
    5-Haloacetamido-5-deoxythymidines: novel inhibitors of thymidylate synthase (1986), Biochim. Biophys. Acta, 881, 175-184.
    View publication on PubMed

Application

Application Comment Organism
medicine
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
5-bromoacetamido-5'-deoxythymidine
-
Mus musculus
5-chloroacetamido-5'-deoxythymidine
-
Mus musculus
5-haloacetamido-5'-deoxythymidine
-
Mus musculus
5-iodoacetamido-5'-deoxythymidine
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0092
-
2'-deoxyuridylate
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP Mus musculus
-
dihydrofolate + dTMP
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
L1210 cells
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
?
5,10-methylenetetrahydrofolate + dUMP
-
Mus musculus dihydrofolate + dTMP
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0054
-
5-bromoacetamido-5'-deoxythymidine competitive inhibition Mus musculus
0.0066
-
5-bromoacetamido-5'-deoxythymidine
-
Mus musculus