BRENDA - Enzyme Database show
show all sequences of 2.1.1.45

Presence and properties of thymidylate synthase in trypanosomatids

Al Chalabi, K.; Gutteridge, W.E.; Biochim. Biophys. Acta 481, 71-79 (1977)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
possible target for chemotherapeutic attack
Crithidia fasciculata
medicine
possible target for chemotherapeutic attack
Strigomonas oncopelti
medicine
possible target for chemotherapeutic attack
Trypanosoma brucei
medicine
possible target for chemotherapeutic attack
Trypanosoma congolense
medicine
possible target for chemotherapeutic attack
Trypanosoma cruzi
medicine
possible target for chemotherapeutic attack
Trypanosoma lewisi
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-mercaptoethanol
-
Crithidia fasciculata
2-mercaptoethanol
-
Strigomonas oncopelti
2-mercaptoethanol
-
Trypanosoma brucei
2-mercaptoethanol
-
Trypanosoma congolense
2-mercaptoethanol
-
Trypanosoma cruzi
2-mercaptoethanol
-
Trypanosoma lewisi
5-fluorouracil
-
Trypanosoma cruzi
5-fluorouracil
-
Crithidia fasciculata
5-fluorouracil
-
Escherichia coli
aminopterin
-
Crithidia fasciculata
aminopterin
-
Trypanosoma cruzi
antrycide
-
Crithidia fasciculata
antrycide
-
Strigomonas oncopelti
antrycide
-
Trypanosoma brucei
antrycide
-
Trypanosoma congolense
antrycide
-
Trypanosoma cruzi
antrycide
-
Trypanosoma lewisi
dimidium
-
Crithidia fasciculata
dimidium
-
Strigomonas oncopelti
dimidium
-
Trypanosoma brucei
dimidium
-
Trypanosoma congolense
dimidium
-
Trypanosoma cruzi
dimidium
-
Trypanosoma lewisi
ethidium
-
Crithidia fasciculata
ethidium
-
Strigomonas oncopelti
ethidium
-
Trypanosoma brucei
ethidium
-
Trypanosoma congolense
ethidium
-
Trypanosoma cruzi
ethidium
-
Trypanosoma lewisi
Mg2+
-
Crithidia fasciculata
Mg2+
-
Strigomonas oncopelti
Mg2+
-
Trypanosoma brucei
Mg2+
-
Trypanosoma congolense
Mg2+
-
Trypanosoma cruzi
Mg2+
-
Trypanosoma lewisi
Pentamidine
-
Crithidia fasciculata
Pentamidine
-
Strigomonas oncopelti
Pentamidine
-
Trypanosoma brucei
Pentamidine
-
Trypanosoma congolense
Pentamidine
-
Trypanosoma cruzi
Pentamidine
-
Trypanosoma lewisi
prothidium
-
Crithidia fasciculata
prothidium
-
Strigomonas oncopelti
prothidium
-
Trypanosoma brucei
prothidium
-
Trypanosoma congolense
prothidium
-
Trypanosoma cruzi
prothidium
-
Trypanosoma lewisi
suramin
-
Crithidia fasciculata
suramin
-
Strigomonas oncopelti
suramin
-
Trypanosoma brucei
suramin
-
Trypanosoma congolense
suramin
-
Trypanosoma cruzi
suramin
-
Trypanosoma lewisi
trimethoprim
-
Trypanosoma cruzi
trimethoprim
-
Crithidia fasciculata
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
175000
-
gel filtration
Crithidia fasciculata
200000
-
gel filtration
Trypanosoma cruzi
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5,10-methylenetetrahydrofolate + dUMP
Escherichia coli
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Rattus norvegicus
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma brucei
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Crithidia fasciculata
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma cruzi
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma congolense
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Strigomonas oncopelti
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma lewisi
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma brucei gambiense
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma rhodesiense
-
dihydrofolate + dTMP
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Crithidia fasciculata
-
host Anopheles strain ATCC 11,745
-
Escherichia coli
-
-
-
Rattus norvegicus
-
-
-
Strigomonas oncopelti
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma brucei gambiense
-
-
-
Trypanosoma congolense
-
causes nagana, the equivalent disease of cattle
-
Trypanosoma cruzi
-
causes Chagas' disease in man; sonya strain, maintained in ASH/XP mice
-
Trypanosoma lewisi
-
natural pathogen of rats
-
Trypanosoma rhodesiense
-
causes human sleeping sickness
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood
intracellular parasites, host blood
Crithidia fasciculata
-
blood
intracellular parasites, host blood
Strigomonas oncopelti
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma brucei
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma congolense
-
blood
intracellular parasites, host blood
Trypanosoma cruzi
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma lewisi
-
fetus
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.00012
-
-
Trypanosoma brucei
0.00014
-
-
Trypanosoma congolense
0.00035
-
intracellular form
Trypanosoma cruzi
0.00038
-
-
Trypanosoma lewisi
0.00054
-
-
Strigomonas oncopelti
0.00119
-
blood form
Trypanosoma cruzi
0.00156
-
culture form
Trypanosoma cruzi
0.00218
-
-
Crithidia fasciculata
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5,10-methylenetetrahydrofolate + dUMP
-
485374
Escherichia coli
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Escherichia coli
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Rattus norvegicus
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Rattus norvegicus
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Crithidia fasciculata
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Crithidia fasciculata
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma cruzi
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma cruzi
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma congolense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma congolense
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Strigomonas oncopelti
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Strigomonas oncopelti
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma lewisi
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma lewisi
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei gambiense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei gambiense
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma rhodesiense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma rhodesiense
dihydrofolate + dTMP
-
-
-
r
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
30
-
-
Crithidia fasciculata
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
6.7
-
Trypanosoma brucei gambiense
6.5
6.7
-
Trypanosoma lewisi
7.8
-
-
Crithidia fasciculata
Application (protein specific)
Application
Commentary
Organism
medicine
possible target for chemotherapeutic attack
Crithidia fasciculata
medicine
possible target for chemotherapeutic attack
Strigomonas oncopelti
medicine
possible target for chemotherapeutic attack
Trypanosoma brucei
medicine
possible target for chemotherapeutic attack
Trypanosoma congolense
medicine
possible target for chemotherapeutic attack
Trypanosoma cruzi
medicine
possible target for chemotherapeutic attack
Trypanosoma lewisi
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-mercaptoethanol
-
Crithidia fasciculata
2-mercaptoethanol
-
Strigomonas oncopelti
2-mercaptoethanol
-
Trypanosoma brucei
2-mercaptoethanol
-
Trypanosoma congolense
2-mercaptoethanol
-
Trypanosoma cruzi
2-mercaptoethanol
-
Trypanosoma lewisi
5-fluorouracil
-
Trypanosoma cruzi
5-fluorouracil
-
Crithidia fasciculata
5-fluorouracil
-
Escherichia coli
aminopterin
-
Crithidia fasciculata
aminopterin
-
Trypanosoma cruzi
antrycide
-
Crithidia fasciculata
antrycide
-
Strigomonas oncopelti
antrycide
-
Trypanosoma brucei
antrycide
-
Trypanosoma congolense
antrycide
-
Trypanosoma cruzi
antrycide
-
Trypanosoma lewisi
dimidium
-
Crithidia fasciculata
dimidium
-
Strigomonas oncopelti
dimidium
-
Trypanosoma brucei
dimidium
-
Trypanosoma congolense
dimidium
-
Trypanosoma cruzi
dimidium
-
Trypanosoma lewisi
ethidium
-
Crithidia fasciculata
ethidium
-
Strigomonas oncopelti
ethidium
-
Trypanosoma brucei
ethidium
-
Trypanosoma congolense
ethidium
-
Trypanosoma cruzi
ethidium
-
Trypanosoma lewisi
Mg2+
-
Crithidia fasciculata
Mg2+
-
Strigomonas oncopelti
Mg2+
-
Trypanosoma brucei
Mg2+
-
Trypanosoma congolense
Mg2+
-
Trypanosoma cruzi
Mg2+
-
Trypanosoma lewisi
Pentamidine
-
Crithidia fasciculata
Pentamidine
-
Strigomonas oncopelti
Pentamidine
-
Trypanosoma brucei
Pentamidine
-
Trypanosoma congolense
Pentamidine
-
Trypanosoma cruzi
Pentamidine
-
Trypanosoma lewisi
prothidium
-
Crithidia fasciculata
prothidium
-
Strigomonas oncopelti
prothidium
-
Trypanosoma brucei
prothidium
-
Trypanosoma congolense
prothidium
-
Trypanosoma cruzi
prothidium
-
Trypanosoma lewisi
suramin
-
Crithidia fasciculata
suramin
-
Strigomonas oncopelti
suramin
-
Trypanosoma brucei
suramin
-
Trypanosoma congolense
suramin
-
Trypanosoma cruzi
suramin
-
Trypanosoma lewisi
trimethoprim
-
Trypanosoma cruzi
trimethoprim
-
Crithidia fasciculata
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
175000
-
gel filtration
Crithidia fasciculata
200000
-
gel filtration
Trypanosoma cruzi
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5,10-methylenetetrahydrofolate + dUMP
Escherichia coli
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Rattus norvegicus
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma brucei
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Crithidia fasciculata
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma cruzi
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma congolense
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Strigomonas oncopelti
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma lewisi
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma brucei gambiense
-
dihydrofolate + dTMP
-
-
?
5,10-methylenetetrahydrofolate + dUMP
Trypanosoma rhodesiense
-
dihydrofolate + dTMP
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood
intracellular parasites, host blood
Crithidia fasciculata
-
blood
intracellular parasites, host blood
Strigomonas oncopelti
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma brucei
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma congolense
-
blood
intracellular parasites, host blood
Trypanosoma cruzi
-
blood
intracellular parasites, host blood; obtained from infected rat blood
Trypanosoma lewisi
-
fetus
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
0.00012
-
-
Trypanosoma brucei
0.00014
-
-
Trypanosoma congolense
0.00035
-
intracellular form
Trypanosoma cruzi
0.00038
-
-
Trypanosoma lewisi
0.00054
-
-
Strigomonas oncopelti
0.00119
-
blood form
Trypanosoma cruzi
0.00156
-
culture form
Trypanosoma cruzi
0.00218
-
-
Crithidia fasciculata
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5,10-methylenetetrahydrofolate + dUMP
-
485374
Escherichia coli
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Escherichia coli
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Rattus norvegicus
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Rattus norvegicus
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Crithidia fasciculata
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Crithidia fasciculata
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma cruzi
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma cruzi
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma congolense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma congolense
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Strigomonas oncopelti
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Strigomonas oncopelti
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma lewisi
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma lewisi
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei gambiense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma brucei gambiense
dihydrofolate + dTMP
-
-
-
r
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma rhodesiense
dihydrofolate + dTMP
-
-
-
?
5,10-methylenetetrahydrofolate + dUMP
-
485374
Trypanosoma rhodesiense
dihydrofolate + dTMP
-
-
-
r
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
30
-
-
Crithidia fasciculata
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
6.7
-
Trypanosoma brucei gambiense
6.5
6.7
-
Trypanosoma lewisi
7.8
-
-
Crithidia fasciculata
Other publictions for EC 2.1.1.45
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743569
Gibson
Trypanosoma brucei DHFR-TS re ...
Trypanosoma brucei, Trypanosoma brucei 427
PLoS Negl. Trop. Dis.
10
e0004714
2016
-
1
1
-
1
-
10
1
-
2
-
3
-
2
-
-
1
-
-
-
1
-
6
1
1
-
-
-
1
-
-
2
7
-
-
-
1
1
2
-
1
-
-
10
7
1
-
2
-
3
-
-
-
1
-
-
1
-
6
1
1
-
-
-
1
-
-
-
1
1
1
1
-
-
743758
Wang
Substrate channeling between ...
Homo sapiens
Protein Sci.
25
79-86
2016
-
-
-
-
-
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18
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Huang
Replacement of Val3 in human t ...
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Biochemical characterization o ...
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Alternative thymidylate syntha ...
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Zhang
Interaction between thymidylat ...
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1
1
1
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720965
Cardinale
Design and characterization of ...
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4
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1
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2
4
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1
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Structures of dihydrofolate re ...
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1
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1
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1
1
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1
1
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Chitnumsub
Crystallization and preliminar ...
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Acta Crystallogr. Sect. F
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1
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1
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1
1
1
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1
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1
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1
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702155
McGuire
Metabolism-blocked antifolates ...
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7
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7
9
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703257
Monica
Differential thymidylate synth ...
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Arvizu-Flores
Functional identity of the act ...
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2
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703950
Bielas
Molecularly evolved thymidylat ...
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1
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8
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1
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8
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-
-
-
-
3
-
-
51
-
-
-
3
-
-
-
51
72
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705333
Kanaan
QM/MM study of thymidylate syn ...
Escherichia coli
J. Phys. Chem. A
113
2176-2182
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706625
Lovelace
Variants of human thymidylate ...
Homo sapiens
Protein Sci.
18
1628-1636
2009
-
-
1
1
4
-
-
5
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
5
-
-
-
1
-
-
-
-
-
1
1
1
4
-
-
-
-
5
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
5
5
706772
Arvizu-Flores
-
Spectroscopic analysis of fola ...
Escherichia coli
Spectrosc. Lett.
42
142-146
2009
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685197
Dasgupta
Probing the role of parasite-s ...
Plasmodium falciparum, Plasmodium falciparum TM4/8.2
Biochemistry
47
1336-1345
2008
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
688294
Gangjee
Design, synthesis, and biologi ...
Escherichia coli, Homo sapiens, Toxoplasma gondii
J. Med. Chem.
51
68-76
2008
-
3
-
-
-
-
16
-
-
-
-
3
-
5
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
16
-
3
-
3
-
-
-
16
16
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688987
Kim
Thymidylate synthase and dihyd ...
Caenorhabditis elegans, Caenorhabditis elegans Bristol N2
Mol. Cells
26
344-349
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
7
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
689059
Sienkiewicz
Chemical and genetic validatio ...
Trypanosoma brucei
Mol. Microbiol.
69
520-533
2008
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
690467
Aboge
Cloning, expression and charac ...
Babesia gibsoni
Antimicrob. Agents Chemother.
52
4072-4080
2008
-
-
1
-
-
-
1
-
2
-
2
1
-
2
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
2
1
-
-
-
2
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690953
Gibson
The R163K mutant of human thym ...
Homo sapiens
Biochemistry
47
4636-4643
2008
-
-
1
1
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691589
Clamp
A phase I and pharmacokinetic ...
Homo sapiens
Cancer Chemother. Pharmacol.
61
579-585
2008
-
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691614
Pillai
Imaging pharmacodynamics of th ...
Homo sapiens
Cancer Res.
68
3827-3834
2008
-
1
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692015
Luo
Uracil incorporation into geno ...
Homo sapiens
DNA Repair
7
162-169
2008
-
1
-
-
1
-
3
-
-
-
-
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692016
Waldman
Induction of intrachromosomal ...
Homo sapiens
DNA Repair
7
1624-1635
2008
-
1
-
-
-
-
1
-
-
-
-
1
-
4
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692639
Arvizu-Flores
Role of an invariant lysine re ...
Escherichia coli
Int. J. Biochem. Cell Biol.
40
2206-2217
2008
-
-
1
1
1
-
2
3
-
-
-
1
-
2
-
-
1
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
2
-
3
-
-
-
1
-
-
-
1
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
693567
Gangjee
Potent dual thymidylate syntha ...
Escherichia coli, Homo sapiens, Toxoplasma gondii
J. Med. Chem.
51
5789-5797
2008
-
1
-
3
-
-
20
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
20
-
1
-
-
3
-
-
20
20
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694120
Okabe
Synergistic antitumor effect o ...
Homo sapiens
Mol. Cancer Ther.
7
599-606
2008
-
1
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
7
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694135
Jung
Novobiocin inhibits the self-s ...
Escherichia virus T4
Mol. Cell. Biochem.
314
143-149
2008
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694481
Codacci-Pisanelli
Selective protection by uridin ...
Homo sapiens, Mus musculus
Nucleosides Nucleotides Nucleic Acids
27
733-739
2008
-
-
-
-
-
-
4
-
-
-
-
2
-
3
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694482
Giovannetti
Functional inactivity and muta ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
27
740-745
2008
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694812
Hunter
Kinetics and ligand-binding pr ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
3
e2237
2008
-
1
1
-
-
-
3
5
-
-
4
1
-
5
-
-
1
-
-
-
1
-
4
2
-
-
-
2
-
-
-
-
4
-
-
-
1
2
-
-
-
-
-
4
5
6
-
-
5
1
-
-
-
2
-
-
2
-
4
3
-
-
-
2
-
-
-
-
-
-
-
-
-
-
695256
Wang
Identification and characteriz ...
Geobacillus virus E2
Virus Genes
37
218-224
2008
-
-
1
-
-
-
-
-
-
-
1
2
-
3
-
-
1
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702544
Jarmula
A molecular modeling study of ...
Escherichia coli
Bioorg. Med. Chem. Lett.
18
2701-2708
2008
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
1
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702996
Showalter
Evaluating the drug-target rel ...
Homo sapiens
Cancer Biol. Ther.
7
986-994
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703220
Ferrari
Sequence-based identification ...
Acinetobacter baumannii, Aeromonas hydrophila, Ascaris suum, Aspergillus clavatus, Aspergillus fischeri, Aspergillus fumigatus, Aspergillus nidulans, Bacillus amyloliquefaciens, Bacillus anthracis, Bacillus cereus, Bacillus licheniformis, Bacillus mycoides, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bartonella bacilliformis, Bartonella henselae, Bartonella quintana, Bordetella bronchiseptica, Bordetella parapertussis, Bordetella pertussis, Brucella abortus, Brucella melitensis, Brucella suis, Burkholderia ambifaria, Burkholderia dolosa, Burkholderia mallei, Burkholderia multivorans, Burkholderia pseudomallei, Burkholderia vietnamiensis, Candida albicans, Candida glabrata, Chaetomium globosum, Chromobacterium violaceum, Clostridioides difficile, Coccidioides immitis, Comamonas testosteroni, Corynebacterium diphtheriae, Corynebacterium jeikeium, Coxiella burnetii, Cryptococcus neoformans, Cryptosporidium hominis, Cryptosporidium parvum, Cutibacterium acnes, Debaryomyces hansenii, Encephalitozoon cuniculi, Enterobacter sp., Enterococcus faecalis, Enterococcus faecium, Francisella tularensis, Fusobacterium nucleatum, Haemophilus ducreyi, Haemophilus influenzae, Human alphaherpesvirus 1, Legionella pneumophila, Leishmania amazonensis, Leishmania braziliensis, Leishmania donovani, Leishmania infantum, Leishmania major, Leishmania tropica, Listeria monocytogenes, Mycobacterium avium, Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycobacterium ulcerans, Mycoplasma genitalium, Mycoplasma penetrans, Mycoplasma pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Nocardia farcinica, Novosphingobium aromaticivorans, Pasteurella multocida, Plasmodium falciparum, Plasmodium malariae, Plasmodium vivax, Pneumocystis carinii, Porphyromonas gingivalis, Pseudomonas aeruginosa, Pseudomonas mendocina, Salmonella enterica, Salmonella enterica subsp. enterica serovar Paratyphi A, Salmonella enterica subsp. enterica serovar Typhi, Salmonella enterica subsp. enterica serovar Typhimurium, Schistosoma japonicum, Serratia proteamaculans, Shewanella putrefaciens, Shigella boydii, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Stenotrophomonas maltophilia, Streptococcus agalactiae, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus sanguinis, Toxoplasma gondii, Trichinella spiralis, Trypanosoma brucei, Trypanosoma cruzi, Vibrio alginolyticus, Vibrio cholerae, Vibrio parahaemolyticus, Vibrio vulnificus, Yersinia bercovieri, Yersinia enterocolitica, Yersinia frederiksenii, Yersinia intermedia, Yersinia mollaretii, Yersinia pestis, Yersinia pseudotuberculosis
ChemMedChem
3
392-401
2008
-
-
-
-
-
-
468
-
-
-
-
-
-
117
-
-
-
-
-
-
-
-
117
-
-
-
-
-
-
-
-
117
-
-
-
-
-
-
117
-
-
-
-
468
-
-
-
-
-
-
-
-
-
-
-
-
-
-
117
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703391
Jason
ODN 491, a novel antisense oli ...
Homo sapiens
DNA Cell Biol.
27
229-240
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
704284
Chatterjee
In vivo mutations of thymidyla ...
Staphylococcus aureus
J. Bacteriol.
190
834-842
2008
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690892
Lovelace
Cooperative inhibition of huma ...
Homo sapiens
Biochemistry
46
2823-2830
2007
-
1
-
1
-
-
2
-
-
-
2
1
-
3
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
2
-
-
-
3
2
-
-
-
2
1
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691522
Giovannetti
Changes in the status of p53 a ...
Homo sapiens
Br. J. Cancer
96
769-775
2007
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
4
-
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1
-
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
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1
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-
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1
-
-
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-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691753
Chernyshev
The relationships between oxid ...
Thermotoga maritima
Chem. Commun. (Camb. )
19
2861-2863
2007
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
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1
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-
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-
-
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-
-
692158
Nief
Involvement of gene polymorphi ...
Homo sapiens
Eur. J. Cancer
43
955-962
2007
-
1
-
-
-
-
1
-
-
-
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1
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2
-
-
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1
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2
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1
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1
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1
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692480
Jason
Antisense targeting of thymidy ...
Homo sapiens
Gene Expr.
13
227-239
2007
-
1
-
-
1
-
5
-
-
-
-
1
-
2
-
-
-
-
-
1
-
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2
-
-
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-
-
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-
1
-
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1
-
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5
-
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1
-
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-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
692655
Curtin
Thymidylate synthase polymorph ...
Homo sapiens
Int. J. Cancer
120
2226-2232
2007
-
1
-
-
-
-
-
-
-
-
-
1
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2
-
-
-
-
-
1
-
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2
-
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-
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-
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1
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1
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694503
Bijnsdorp
Mechanisms of action of FdUMP[ ...
Mus musculus
Oncol. Rep.
18
287-291
2007
-
1
-
-
-
-
11
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
9
-
1
-
-
-
-
-
9
11
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695129
Yan
In vitro selected peptides bin ...
Homo sapiens
Sci. China C Life Sci.
50
630-636
2007
-
1
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
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1
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1
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-
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-
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695194
Giudice
New thymidylate synthase inhib ...
Homo sapiens
Toxicol. in Vitro
21
240-248
2007
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
-
-
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2
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-
-
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-
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-
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3
-
-
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657899
Leduc
Two distinct pathways for thym ...
Archaeoglobus fulgidus, Methanocaldococcus jannaschii, Methanopyrus kandleri, Methanothermobacter thermautotrophicus, no activity in Aeropyrum pernix, no activity in Aquifex aeolicus, no activity in Pyrobaculum aerophilum, no activity in Pyrococcus abyssi, no activity in Pyrococcus furiosus, no activity in Pyrococcus horikoshii, no activity in Sulfolobus solfataricus, no activity in Sulfolobus tokodaii, no activity in Thermoplasma acidophilum, no activity in Thermoplasma volcanium, no activity in Thermotoga maritima
Biochem. Soc. Trans.
32
231-235
2004
-
-
-
-
-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485432
Fritz
Tryptophan 80 and leucine 143 ...
Escherichia coli
Biochemistry
41
7021-7029
2002
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485433
Kawate
Distribution of mutations in h ...
Homo sapiens
J. Biol. Chem.
277
36304-36311
2002
-
1
1
1
-
-
-
5
-
-
1
1
-
2
-
-
1
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
5
-
-
1
1
-
-
-
1
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485430
Golos
Interaction of thymidylate syn ...
Escherichia coli, Homo sapiens, Lactobacillus casei, Mus musculus, Pneumocystis carinii, Rattus norvegicus, Trichinella pseudospiralis, Trichinella spiralis
Biol. Chem.
382
1439-1445
2001
-
4
1
3
-
-
11
6
-
-
-
8
-
8
-
-
2
-
-
3
-
-
20
-
-
-
-
-
1
1
-
-
2
-
-
-
4
1
-
3
-
-
-
11
2
6
-
-
-
8
-
-
-
2
-
3
-
-
20
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
485431
Saxl
Parameters affecting the resto ...
Escherichia coli, Lactobacillus casei, Pneumocystis carinii
Biochemistry
40
5275-5282
2001
-
-
1
3
-
-
2
-
-
2
-
3
-
4
-
-
1
-
-
-
-
-
6
3
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
2
-
-
-
2
-
3
-
-
-
1
-
-
-
-
6
3
-
1
1
-
-
-
-
-
-
-
-
-
-
-
485424
Anderson
The crystal structure of thymi ...
Pneumocystis carinii
J. Mol. Biol.
297
645-657
2000
-
1
-
1
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485425
Changchien
High-Level expression of Esche ...
Bacillus subtilis, Escherichia coli
Protein Expr. Purif.
19
265-270
2000
2
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
2
-
-
-
-
1
4
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
1
4
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
485426
Fantz
Drug-resistant variants of Esc ...
Escherichia coli, Homo sapiens, Mus musculus
Mol. Pharmacol.
57
359-366
2000
-
2
1
2
-
-
-
10
-
-
-
3
-
5
-
-
2
-
-
2
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
-
-
-
10
-
-
-
3
-
-
-
2
-
2
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
485427
Felczak
5-Substituted N4-hydroxy-2'-de ...
Lactobacillus casei, Mus musculus, Rattus norvegicus, Trichinella spiralis
J. Med. Chem.
43
4647-4656
2000
-
-
1
-
-
-
16
-
-
-
-
4
-
6
-
-
-
-
-
2
1
-
13
-
-
-
-
-
-
-
-
1
18
-
-
-
-
1
1
-
-
-
-
16
18
-
-
-
-
4
-
-
-
-
-
2
1
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485428
Jarmula
Different activities of 5-hydr ...
Homo sapiens
Bioorg. Chem.
28
156-162
2000
-
1
-
1
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485429
Phan
Catalytic cysteine of thymidyl ...
Escherichia coli, Homo sapiens, Lactobacillus casei
Biochemistry
39
6969-6978
2000
-
2
1
2
-
-
-
16
-
-
1
3
-
4
-
-
-
-
-
-
-
-
8
3
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
-
-
-
16
-
-
1
3
-
-
-
-
-
-
-
-
8
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485420
Anderson
The structural mechanism for h ...
Pneumocystis carinii
Biochemistry
38
13829-13836
1999
-
-
-
1
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
1
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485421
Fox
Crystal structure of thymidyla ...
Bacillus subtilis, Escherichia coli
Protein Sci.
8
538-544
1999
-
-
1
1
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485422
Mahdavian
Kinetic studies on drug-resist ...
Escherichia coli, Homo sapiens
Arch. Biochem. Biophys.
368
257-264
1999
-
1
2
2
-
-
-
9
-
-
-
2
-
4
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
1
2
1
2
-
-
-
-
-
9
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485423
Steadman
Substitution at residue 214 of ...
Escherichia coli, Homo sapiens, Lactobacillus casei
Biochemistry
38
5582-5587
1999
-
-
1
2
-
-
5
-
-
-
-
3
-
4
-
-
2
-
-
-
-
-
9
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
5
-
-
-
-
-
3
-
-
-
2
-
-
-
-
9
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
485416
Chiericatti
Aspartate 221 of thymidylate s ...
Escherichia coli, Lactobacillus casei
Biochemistry
37
9038-9042
1998
-
-
-
1
-
-
-
19
-
-
-
2
-
3
-
-
1
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
19
-
-
-
2
-
-
-
1
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485417
Liang
Substrate channeling and domai ...
Escherichia coli, Leishmania major, Toxoplasma gondii
Biochemistry
37
12195-12205
1998
-
-
1
1
-
-
2
-
-
-
-
3
-
5
-
-
-
-
-
-
-
-
10
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
10
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
485418
Stout
Crystal structures of a unique ...
Bacillus phage phi3T, Bacillus subtilis, Escherichia coli, Lactobacillus casei, Lactococcus lactis
Biochemistry
37
14736-14747
1998
-
-
1
1
-
-
-
-
-
-
-
5
-
9
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485419
Tong
Isolation and characterization ...
Cryptococcus neoformans, Cryptococcus neoformans B-3501A, Escherichia coli, Homo sapiens, Lactobacillus casei
J. Biol. Chem.
273
11611-11618
1998
-
3
1
1
-
-
9
-
-
-
-
5
-
8
-
-
2
-
-
-
-
-
10
-
-
-
-
-
-
-
-
1
-
-
-
-
3
1
1
1
-
-
-
9
-
-
-
-
-
5
-
-
-
2
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485414
Carlson
Identification and characteriz ...
Bacillus subtilis, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria gonorrhoeae MS11
FEMS Microbiol. Lett.
151
225-230
1997
-
-
1
-
-
-
1
-
-
-
-
4
-
9
-
-
1
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485415
Spencer
Kinetic scheme for thymidylate ...
Candida albicans, Escherichia coli, Escherichia virus T4, Homo sapiens, Lactobacillus casei, Mus musculus
Biochemistry
36
4212-4222
1997
-
4
6
-
-
-
5
1
-
-
1
6
-
8
-
-
1
-
-
-
-
-
18
5
-
-
-
-
-
-
-
-
1
-
-
-
4
6
-
-
-
-
-
5
1
1
-
-
1
6
-
-
-
1
-
-
-
-
18
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485409
Cho
-
Effects of mutation at arginin ...
Escherichia coli, Escherichia virus T4, Lactobacillus casei, Plasmodium falciparum
Exp. Mol. Med.
28
77-83
1996
-
-
2
1
-
-
1
-
-
-
-
4
-
4
-
-
-
-
-
-
-
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8
-
-
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-
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2
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1
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1
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4
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8
-
-
-
-
-
-
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-
-
-
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-
-
-
-
485410
Finer-Moore
Partitioning roles of side cha ...
Lactobacillus casei, Lactobacillus casei TS N229D
Biochemistry
35
5125-5136
1996
-
-
-
1
-
-
-
7
-
-
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2
-
2
-
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8
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1
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7
-
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2
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-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485411
Gokhale
Covalent reinforcement of a fr ...
Escherichia virus T4, Lactobacillus casei
Biochemistry
35
7150-7158
1996
-
-
1
1
1
-
1
-
-
-
3
2
-
2
-
-
-
-
-
-
-
-
4
2
1
1
2
-
-
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-
1
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1
-
1
1
-
-
1
1
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3
2
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-
-
-
4
2
1
1
2
-
-
-
-
-
-
-
-
-
-
-
485413
Hekmat-Nejad
Kinetics of Plasmodium flacipa ...
Crithidia fasciculata, Escherichia coli, Homo sapiens, Leishmania major, Mus musculus, Plasmodium berghei, Plasmodium falciparum, Plasmodium yoelii
Antimicrob. Agents Chemother.
40
1628-1632
1996
-
5
1
-
-
-
15
9
-
-
4
8
-
9
-
-
1
-
-
-
1
-
22
6
-
-
-
-
-
-
-
-
7
-
-
-
5
1
-
-
-
-
-
15
7
9
-
-
4
8
-
-
-
1
-
-
1
-
22
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485405
Garcia-Fuentes
Thermodynamic analysis of the ...
Escherichia coli, Lactobacillus casei
Eur. J. Biochem.
232
641-645
1995
-
1
1
2
-
-
1
-
-
-
1
2
-
3
-
-
1
-
-
-
1
-
4
2
-
1
-
-
-
-
-
2
-
-
-
-
1
1
2
2
-
-
-
1
-
-
-
-
1
2
-
-
-
1
-
-
1
-
4
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
485406
Maley
Complete restoration of activi ...
Escherichia coli, Lactobacillus casei
Biochemistry
34
1469-1474
1995
-
-
-
2
-
-
-
-
-
-
-
2
-
4
-
-
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-
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4
2
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-
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2
-
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2
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-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485407
Schiffer
Crystal structure of human thy ...
Homo sapiens
Biochemistry
34
16279-16287
1995
-
1
-
1
-
-
-
-
-
-
-
1
-
3
-
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2
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1
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1
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1
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485408
Voeller
Characterization of a specific ...
Enterococcus faecium, Escherichia coli, Escherichia virus T4, Homo sapiens
Nucleic Acids Res.
23
869-875
1995
-
2
1
1
-
-
-
-
-
-
1
6
-
6
-
-
2
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
1
-
-
-
-
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-
1
6
-
-
-
2
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485403
Livi
Cloning, expression and charac ...
Candida albicans, Cryptococcus neoformans, Cryptococcus neoformans B-3501A, Escherichia virus T4, Homo sapiens, Lactobacillus casei, Mus musculus, Pneumocystis carinii
Gene
150
221-226
1994
-
5
2
-
-
1
1
2
-
-
2
8
-
11
-
-
1
-
-
-
1
3
16
-
-
-
-
-
2
-
1
-
-
-
-
-
5
2
-
-
-
1
-
1
-
2
-
-
2
8
-
-
-
1
-
-
1
3
16
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
485404
So
Angiostrongylus cantonensis: C ...
Aedes aegypti, Angiostrongylus cantonensis, Bos taurus, Brugia pahangi, Candida albicans, Crithidia fasciculata, Gallus gallus, Homo sapiens, Leishmania major, Mus musculus, Plasmodium falciparum, Rattus norvegicus, Saccharomyces cerevisiae, Sus scrofa, Toxoplasma gondii
Exp. Parasitol.
79
526-535
1994
-
5
1
-
-
-
17
2
-
-
3
17
-
17
-
-
7
-
-
13
1
1
36
8
-
-
-
-
-
-
-
-
20
-
-
-
5
1
-
-
-
-
-
17
20
2
-
-
3
17
-
-
-
7
-
13
1
1
36
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485401
Chen
1-Phenyl-3-trimethylaminopropy ...
Lactobacillus casei
J. Enzyme Inhib.
5
259-268
1992
-
-
-
-
-
-
3
-
-
-
-
1
-
2
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2
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3
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1
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485402
Galova
Characteristics of NADPH-depen ...
Bos taurus, Crithidia fasciculata, Escherichia coli, Kitasatospora aureofaciens, Mus musculus, Saccharomyces cerevisiae
Arch. Biochem. Biophys.
296
81-87
1992
6
-
-
-
-
1
4
5
-
1
2
6
-
7
-
-
1
-
-
-
1
1
15
5
2
1
-
-
4
-
-
1
-
-
-
6
-
-
1
-
-
1
-
4
-
5
-
1
2
6
-
-
-
1
-
-
1
1
15
5
2
1
-
-
4
-
-
-
-
-
-
-
-
-
485398
Balinska
Inhibition of mammalian thymid ...
Homo sapiens, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
284
219-222
1991
-
-
-
-
-
-
13
2
-
-
-
3
-
3
-
-
1
-
-
3
-
-
13
-
-
-
-
-
-
-
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-
6
-
-
-
-
-
-
-
-
-
-
13
6
2
-
-
-
3
-
-
-
1
-
3
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485399
Bures
Inhibition of thymidylate synt ...
Lactobacillus casei
Int. J. Biochem.
23
733-736
1991
-
-
-
-
-
-
1
-
-
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-
1
-
2
-
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-
-
-
-
-
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2
-
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-
-
-
-
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-
1
-
-
-
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-
-
-
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1
1
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-
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-
1
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-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485400
Zhang
Purification and characterizat ...
Homo sapiens, Lactobacillus casei, Mus musculus
Biochim. Biophys. Acta
1077
35-46
1991
-
2
2
-
-
1
3
-
-
-
-
3
-
5
-
-
1
-
-
-
2
3
6
-
-
-
-
-
1
1
-
-
-
-
-
-
2
2
-
-
-
1
-
3
-
-
-
-
-
3
-
-
-
1
-
-
2
3
6
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
485397
Matthews
Stereochemical mechanism of ac ...
Escherichia coli, Lactobacillus casei
J. Mol. Biol.
214
937-948
1990
-
-
1
1
-
-
4
-
-
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1
2
-
3
-
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-
-
-
-
-
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4
2
-
-
-
-
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3
-
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1
3
1
-
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-
4
-
-
-
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1
2
-
-
-
-
-
-
-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485396
Chen
Inhibition of thymidylate synt ...
Lactobacillus casei
Int. J. Biochem.
21
1217-1221
1989
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485394
Nielsen
-
Thymidylate synthase in plant ...
Daucus carota
Plant Cell Physiol.
29
503-508
1988
-
-
-
-
-
-
1
-
-
-
1
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485395
Radparvar
Characteristics of thymidylate ...
Homo sapiens, Sus scrofa
Arch. Biochem. Biophys.
260
342-350
1988
-
1
-
-
-
-
9
8
-
-
-
2
-
4
-
-
1
-
-
6
1
-
5
-
-
-
-
-
-
-
-
-
7
-
-
-
1
-
-
-
-
-
-
9
7
8
-
-
-
2
-
-
-
1
-
6
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392255
Bachmann
Deoxyribonucleotide biosynthes ...
Abies sp., Bos taurus, Chlamydomonas reinhardtii, Daucus carota, Leishmania major, Mus musculus, Nicotiana tabacum, Saccharomyces cerevisiae, Tetradesmus obliquus
Arch. Biochem. Biophys.
256
244-252
1987
-
-
-
-
-
1
9
-
-
-
4
9
-
13
-
-
1
-
-
2
1
2
19
5
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
9
-
-
-
-
4
9
-
-
-
1
-
2
1
2
19
5
1
-
-
-
1
1
-
-
-
-
-
-
-
-
485393
Nakata
Purification and characterizat ...
Homo sapiens, Lactobacillus casei, Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar, Saccharomyces cerevisiae
Biochim. Biophys. Acta
924
297-302
1987
-
-
-
-
-
-
11
2
-
-
4
6
-
171
-
-
2
-
-
4
-
1
14
6
-
-
-
1
1
-
1
-
7
-
-
-
-
-
-
-
-
-
-
11
7
2
-
-
4
6
-
-
-
2
-
4
-
1
14
6
-
-
-
1
1
-
1
-
-
-
-
-
-
-
485391
Sani
5-Haloacetamido-5-deoxythymidi ...
Mus musculus
Biochim. Biophys. Acta
881
175-184
1986
-
1
-
-
-
-
4
1
-
-
-
1
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
4
2
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485390
Kanai
Vanoxonin, a new inhibitor of ...
Mus musculus
J. Antibiot.
38
39-50
1985
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485389
Pattanakitsakul
Characterization of thymidylat ...
Crithidia fasciculata, Escherichia coli, Homo sapiens, Lactobacillus casei, Leishmania major, Plasmodium berghei, Streptococcus pneumoniae
Int. J. Parasitol.
14
513-520
1984
-
3
-
-
-
-
6
2
-
-
5
7
-
8
-
-
2
-
-
1
1
1
14
6
-
-
-
-
1
-
1
-
2
-
-
-
3
-
-
-
-
-
-
6
2
2
-
-
5
7
-
-
-
2
-
1
1
1
14
6
-
-
-
-
1
-
1
-
-
-
-
-
-
-
485388
Belfort
Purification and properties of ...
Bacillus subtilis, Enterobacteria phage T2, Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia virus T4, Lactobacillus casei, Rattus norvegicus
J. Biol. Chem.
258
2045-2051
1983
-
3
1
-
-
-
5
-
-
-
2
7
-
184
-
-
2
-
-
-
-
-
14
6
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
5
-
-
-
-
2
7
-
-
-
2
-
-
-
-
14
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485387
Banerjee
A convenient procedure for pur ...
Gallus gallus, Homo sapiens, Lactobacillus casei, Mus musculus
Anal. Biochem.
121
275-280
1982
-
3
-
-
-
-
4
-
-
-
6
4
-
4
-
-
3
-
-
5
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
4
-
-
-
-
6
4
-
-
-
3
-
5
-
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485384
Bisson
Thymidylate synthetase from Sa ...
Enterococcus faecalis, Gallus gallus, Homo sapiens, Lactobacillus casei, Mus musculus, Saccharomyces cerevisiae
J. Biol. Chem.
256
12456-12462
1981
-
-
-
-
-
-
12
2
-
-
4
6
-
7
-
-
1
-
-
2
1
-
12
5
-
-
-
-
1
-
1
-
9
-
-
-
-
-
-
-
-
-
-
12
9
2
-
-
4
6
-
-
-
1
-
2
1
-
12
5
-
-
-
-
1
-
1
-
-
-
-
-
-
-
485385
Kalman
Inactivation of thymidylate sy ...
Lactobacillus casei
Biochem. Biophys. Res. Commun.
102
682-689
1981
-
-
-
-
-
-
5
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
5
2
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485386
Priest
Purification of mouse liver th ...
Mus musculus
Experientia
37
119-120
1981
-
1
-
-
-
-
-
-
-
-
1
1
-
2
-
-
1
-
-
2
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
2
1
1
2
1
-
-
-
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-
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-
-
-
-
-
-
-
-
485383
Slavik
Purification of thymidylate sy ...
Bos taurus, Escherichia coli, Escherichia coli B / ATCC 11303, Lactobacillus casei, Mus musculus
Methods Enzymol.
66
709-723
1980
-
-
-
-
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2
7
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-
6
5
-
180
-
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1
-
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2
4
5
11
4
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2
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7
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6
5
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1
-
2
4
5
11
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485380
Haertle
Thymidylate synthetase from Es ...
Enterobacteria phage T2, Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia coli EM 20031 K12, Lactobacillus casei, Streptococcus pneumoniae
Eur. J. Biochem.
102
223-230
1979
-
-
-
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5
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3
4
6
-
182
-
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1
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-
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2
1
23
4
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1
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5
-
3
4
6
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1
-
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2
1
23
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485381
Lockshin
Thymidylate synthetase purifie ...
Bos taurus, Enterobacteria phage T2, Escherichia coli, Homo sapiens, Lactobacillus casei
Proc. Natl. Acad. Sci. USA
76
750-754
1979
2
3
-
-
-
2
-
-
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2
7
-
7
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3
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4
2
2
12
5
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1
1
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2
3
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2
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2
7
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3
-
4
2
2
12
5
-
-
-
1
1
-
-
-
-
-
-
-
-
-
485382
Rode
Purification of mammalian tumo ...
Escherichia coli, Homo sapiens, Lactobacillus casei, Mus musculus
J. Biol. Chem.
254
11538-11543
1979
-
-
-
-
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1
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6
4
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5
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2
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1
1
8
4
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1
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6
4
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2
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1
1
8
4
-
-
-
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-
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-
-
485376
Dolnick
Human thymidylate synthetase. ...
Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia coli R2, Homo sapiens, Lactobacillus casei
J. Biol. Chem.
253
3563-3567
1978
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2
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-
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5
3
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5
-
182
-
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1
-
-
1
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11
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2
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5
-
3
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5
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1
-
1
-
-
11
-
-
-
-
-
-
-
-
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-
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-
-
-
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485377
Dunlap
TMP synthetase from Lactobacil ...
Lactobacillus casei
Methods Enzymol.
51
90-97
1978
-
-
-
-
-
1
8
4
-
1
2
1
-
2
-
-
1
-
-
-
1
1
3
1
-
-
-
-
2
-
-
1
-
-
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-
-
-
1
-
-
1
-
8
-
4
-
1
2
1
-
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-
1
-
-
1
1
3
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
485378
Mertes
5-Nitro-2-deoxyuridine 5-monop ...
Lactobacillus casei
Biochem. Biophys. Res. Commun.
84
1054-1059
1978
-
-
-
-
-
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6
1
-
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1
-
2
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1
-
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2
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3
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6
3
1
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1
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1
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-
2
-
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-
-
-
-
-
-
-
-
-
-
-
-
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485379
Whiteley
5-Fluoro-2-deoxyuridylate-agar ...
Lactobacillus casei
Methods Enzymol.
51
98-104
1978
-
-
-
-
-
-
3
-
-
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1
-
1
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1
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1
-
2
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3
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1
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1
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1
-
2
-
-
-
-
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-
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-
-
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-
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485374
Al Chalabi
Presence and properties of thy ...
Crithidia fasciculata, Escherichia coli, Rattus norvegicus, Strigomonas oncopelti, Trypanosoma brucei, Trypanosoma brucei gambiense, Trypanosoma congolense, Trypanosoma cruzi, Trypanosoma lewisi, Trypanosoma rhodesiense
Biochim. Biophys. Acta
481
71-79
1977
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6
-
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-
55
-
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2
10
-
15
-
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8
8
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20
-
1
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-
3
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6
-
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-
-
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55
-
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2
10
-
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8
8
-
20
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
485375
Danenberg
Thymidylate synthetase - a tar ...
Enterococcus faecalis, Escherichia coli, Escherichia coli B / ATCC 11303, Homo sapiens, Lactobacillus casei, Mus musculus, Streptococcus pneumoniae
Biochim. Biophys. Acta
473
73-92
1977
-
3
-
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-
-
32
-
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11
-
182
-
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1
-
-
3
2
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26
-
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3
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3
-
-
-
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32
3
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11
-
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1
-
3
2
-
26
-
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-
-
-
-
-
-
-
-
485373
Slavik
Purification of thymidylate sy ...
Bos taurus, Escherichia coli, Escherichia coli B / ATCC 11303, Mus musculus
Biochemistry
15
4222-4227
1976
-
-
-
-
-
-
3
-
-
-
-
4
-
181
-
-
3
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2
1
1
8
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1
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3
1
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4
-
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3
-
2
1
1
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485371
Friedkin
Inhibition of thymidylate synt ...
Escherichia coli, Escherichia coli B / ATCC 11303
J. Biol. Chem.
250
5614-5621
1975
-
-
-
-
-
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3
-
-
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2
-
179
-
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4
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3
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2
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-
-
-
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485372
McCuen
Thymidylate synthetase from Di ...
Enterococcus faecium, Escherichia coli, Escherichia coli B / ATCC 11303, Gallus gallus, Lactobacillus casei, Streptococcus pneumoniae
Biochim. Biophys. Acta
384
369-380
1975
-
-
-
-
-
-
12
2
-
3
6
6
-
182
-
-
-
-
-
1
1
-
13
3
-
-
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-
1
1
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-
11
-
-
-
-
-
-
-
-
-
-
12
11
2
-
3
6
6
-
-
-
-
-
1
1
-
13
3
-
-
-
-
1
1
-
-
-
-
-
-
-
-
485367
Carpenter
Properties and inhibition of t ...
Drosophila melanogaster
J. Insect Physiol.
20
1389-1401
1974
-
-
-
-
-
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4
-
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1
-
2
-
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2
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1
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4
-
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1
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-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
485368
Danenberg
-
Purification of thymidylate sy ...
Lactobacillus casei, Mus musculus
Methods Enzymol.
34 B
520-523
1974
-
-
-
-
-
-
-
-
-
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2
-
2
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2
-
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4
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2
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2
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-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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485369
Galivan
Purification and properties of ...
Bos taurus, Enterobacteria phage T2, Enterobacteria phage T6, Escherichia coli, Escherichia virus T4, Lactobacillus casei, Mus musculus, Rattus norvegicus
Biochemistry
13
2282-2289
1974
-
-
-
-
-
-
5
-
-
-
2
8
-
8
-
-
2
-
-
4
3
1
17
7
-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
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5
-
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2
8
-
-
-
2
-
4
3
1
17
7
-
-
-
1
1
-
-
-
-
-
-
-
-
-
485370
Kisliuk
Polyglutamyl derivatives of fo ...
Lactobacillus casei
J. Biol. Chem.
249
4100-4103
1974
-
-
-
-
-
-
5
3
-
-
-
1
-
1
-
-
-
-
-
-
-
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6
-
-
-
-
-
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-
-
-
-
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-
-
-
-
-
-
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5
-
3
-
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1
-
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-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485366
Capco
Bacteriophage-coded thymidylat ...
Escherichia virus T4, Escherichia virus T5, Lactobacillus casei
Arch. Biochem. Biophys.
158
726-735
1973
-
-
-
-
-
2
3
-
-
-
3
3
-
3
-
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2
-
-
-
2
-
6
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
-
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-
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3
3
-
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2
-
-
2
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485361
Danenberg
Purification of thymidylate sy ...
Lactobacillus casei, Mus musculus
Biochem. Biophys. Res. Commun.
49
1029-1033
1972
-
2
-
-
-
-
-
-
-
-
-
2
-
3
-
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1
-
-
-
-
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4
-
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-
-
-
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-
-
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-
2
-
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-
-
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-
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2
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-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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485362
Gupta
-
Purification and properties of ...
Sus scrofa
Can. J. Biochem.
50
353-362
1972
1
-
-
-
-
-
-
-
-
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-
1
-
1
-
-
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-
-
1
-
-
3
-
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-
-
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2
-
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1
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1
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-
1
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
485363
Horinishi
Purification and properties of ...
Bos taurus, Enterobacteria phage T2, Enterobacteria phage T6, Enterococcus faecalis, Escherichia coli, Gallus gallus, Lactobacillus casei, Mus musculus
Biochim. Biophys. Acta
258
741-752
1972
3
-
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1
-
1
8
10
-
-
-
8
-
8
-
-
3
-
-
3
3
-
16
-
-
-
1
-
5
1
-
-
3
-
-
3
-
-
-
1
-
1
-
8
3
10
-
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8
-
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3
-
3
3
-
16
-
-
-
1
-
5
1
-
-
-
-
-
-
-
-
485364
Loeble
Characterization of the subuni ...
Homo sapiens, Lactobacillus casei
Biochem. Biophys. Res. Commun.
49
1671-1677
1972
-
2
-
-
-
-
-
-
-
-
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2
-
2
-
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1
-
-
-
-
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4
2
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-
-
-
-
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2
-
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-
-
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-
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2
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1
-
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-
-
4
2
-
-
-
-
-
-
-
-
-
-
-
-
-
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485365
Santi
Irreversible inhibition of thy ...
Escherichia coli, Escherichia coli B / ATCC 11303, Lactobacillus casei, Mus musculus
Biochem. Biophys. Res. Commun.
46
1320-1325
1972
-
-
-
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1
3
-
-
-
-
4
-
179
-
-
1
-
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8
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2
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2
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-
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1
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3
2
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4
-
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1
-
-
-
-
8
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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485359
Fridland
Purification of thymidylate sy ...
Bos taurus, Enterococcus faecalis, Escherichia coli, Gallus gallus, Homo sapiens, Lactobacillus casei, Mus musculus
J. Biol. Chem.
246
7110-7114
1971
4
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-
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1
7
2
-
-
9
7
-
7
-
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1
-
-
4
-
1
14
1
-
-
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-
1
1
-
-
-
-
-
4
-
-
-
-
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1
-
7
-
2
-
-
9
7
-
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1
-
4
-
1
14
1
-
-
-
-
1
1
-
-
-
-
-
-
-
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485360
Kalman
On the mechanism of the reacti ...
Lactobacillus casei, Mus musculus
Ann. N. Y. Acad. Sci.
186
166-167
1971
-
-
-
-
-
-
-
-
-
-
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2
-
2
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2
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4
-
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2
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2
-
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-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485358
Blakeley
-
The biosythesis of thymidylic ...
Enterococcus faecalis, Escherichia coli, Homo sapiens
J. Biol. Chem.
238
2113-2118
1963
6
-
-
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10
7
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6
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3
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2
-
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1
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15
-
-
-
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-
-
-
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-
3
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6
-
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-
-
-
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10
3
7
-
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6
-
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2
-
1
-
-
15
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485357
Wahba
The enzymatic synthesis of thy ...
Enterococcus faecalis, Escherichia coli, Escherichia coli B / ATCC 11303
J. Biol. Chem.
237
3794-3801
1962
-
-
-
-
-
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3
2
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1
-
3
-
180
-
-
1
-
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-
1
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8
-
-
-
-
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1
2
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-
-
-
-
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-
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-
-
-
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3
-
2
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1
-
3
-
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1
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1
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8
-
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-
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1
2
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