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Literature summary for 2.1.1.44 extracted from
- The enzymatic alpha-N-methylation of histidine (1970), J. Biol. Chem., 245, 5967-5973.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | - |
Neurospora crassa |  |
| Co2+ | - |
Neurospora crassa | |
| Cu2+ | - |
Neurospora crassa | |
| Fe2+ | - |
Neurospora crassa | |
| Fe3+ | - |
Neurospora crassa | |
| hercynine | - |
Neurospora crassa | |
| Hg2+ | - |
Neurospora crassa | |
| histidine | inhibits reaction with dimethylhistidine | Neurospora crassa | |
| Imidazolepropionate | - |
Neurospora crassa | |
| methylhistidine | inhibits reaction with dimethylhistidine | Neurospora crassa | |
| Ni2+ | - |
Neurospora crassa | |
| S-adenosyl-L-homocysteine | - |
Neurospora crassa | |
| Sn2+ | - |
Neurospora crassa | |
| Zn2+ | - |
Neurospora crassa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 270000 | 300000 | gel filtration | Neurospora crassa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histidine | Neurospora crassa | - |
S-adenosyl-L-homocysteine + Nalpha-methylhistidine | - |
? | |
| S-adenosyl-L-methionine + methylhistidine | Neurospora crassa | - |
S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine | - |
? | |
| S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine | Neurospora crassa | - |
S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neurospora crassa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Neurospora crassa |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0434 | - |
- |
Neurospora crassa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | conversion of histidine to hercynine is mediated either by one enzyme or by two or three enzymes with chemical and physical properties so similar that common methods of protein fractionation fail to effect any separation | Neurospora crassa | ? | - |
? | |
| S-adenosyl-L-methionine + histidine | - |
Neurospora crassa | S-adenosyl-L-homocysteine + Nalpha-methylhistidine | - |
? | |
| S-adenosyl-L-methionine + methylhistidine | - |
Neurospora crassa | S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine | - |
? | |
| S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine | - |
Neurospora crassa | S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine | - |
? | |
| S-adenosyl-L-methionine + Nalpha-methylhistidine | - |
Neurospora crassa | S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | histidine | Neurospora crassa |
| 8.5 | 9 | dimethylhistidine | Neurospora crassa |
| 9 | 9.5 | methylhistidine | Neurospora crassa |
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Release 2023.1 (January 2023)
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